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Diversity of RNA Viruses of Three Dominant Tick Species in North China

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Journal Front Vet Sci
Date 2023 Jan 30
PMID 36713863
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Abstract

Background: A wide range of bacterial pathogens have been identified in ticks, yet the diversity of viruses in ticks is largely unexplored.

Methods: Here, we used metagenomic sequencing to characterize the diverse viromes in three principal tick species associated with pathogens, , and , in North China.

Results: A total of 28 RNA viruses were identified and belonged to more than 12 viral families, including single-stranded positive-sense RNA viruses (, and ), negative-sense RNA viruses (, and others) and double-stranded RNA viruses ( and ). Of these, Dermacentor pestivirus-likevirus, Chimay-like rhabdovirus, taiga tick nigecruvirus, and Mukawa virus are presented as novel viral species, while Nuomin virus, Scapularis ixovirus, Sara tick-borne phlebovirus, Tacheng uukuvirus, and Beiji orthonairovirus had been established as human pathogens with undetermined natural circulation and pathogenicity. Other viruses include Norway mononegavirus 1, Jilin partitivirus, tick-borne tetravirus, Pico-like virus, Luteo-like virus 2, Luteo-likevirus 3, Vovk virus, Levivirus, Toti-like virus, and Solemo-like virus as well as others with unknown pathogenicity to humans and wild animals.

Conclusion: In conclusion, extensive virus diversity frequently occurs in and among the three tick species. Comparatively, ticks had been demonstrated as such a kind of host with a significantly higher diversity of viral species than those of and ticks. Our analysis supported that ticks are reservoirs for a wide range of viruses and suggested that the discovery and characterization of tick-borne viruses would have implications for viral taxonomy and provide insights into tick-transmitted viral zoonotic diseases.

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References
1.
Penalver E, Arillo A, Delclos X, Peris D, Grimaldi D, Anderson S . parasitised feathered dinosaurs as revealed by Cretaceous amber assemblages. Nat Commun. 2017; 8(1):1924. PMC: 5727220. DOI: 10.1038/s41467-017-01550-z. View

2.
Pettersson J, Ellstrom P, Ling J, Nilsson I, Bergstrom S, Gonzalez-Acuna D . Circumpolar diversification of the Ixodes uriae tick virome. PLoS Pathog. 2020; 16(8):e1008759. PMC: 7425989. DOI: 10.1371/journal.ppat.1008759. View

3.
Wang Y, Jiang R, Ding H, Zhang X, Wang N, Zhang Y . First Detection of Mukawa Virus in and in China. Front Microbiol. 2022; 13:791563. PMC: 8930188. DOI: 10.3389/fmicb.2022.791563. View

4.
Madison-Antenucci S, Kramer L, Gebhardt L, Kauffman E . Emerging Tick-Borne Diseases. Clin Microbiol Rev. 2020; 33(2). PMC: 6941843. DOI: 10.1128/CMR.00083-18. View

5.
McMullan L, Folk S, Kelly A, MacNeil A, Goldsmith C, Metcalfe M . A new phlebovirus associated with severe febrile illness in Missouri. N Engl J Med. 2012; 367(9):834-41. DOI: 10.1056/NEJMoa1203378. View