Dehydrogenative Syntheses of Biazoles Via a "Pre-Join" Approach

Overview

Journal JACS Au

Publisher American Chemical Society

Specialty Chemistry

Date 2023 Jan 30

PMID 36711107

Authors

Tianyang Yu

Yan Wang

Yaqun Dong

Derui Han

Ning Liu

Bozhou Wang

Yongxing Tang

Hao Wei

Affiliations

Soon will be listed here.

Abstract

The structural motif of biazoles is the predominant substructure of many natural products, pharmaceuticals, and organic materials. Considerable efforts have focused on synthesizing these compounds; however, a limited number of processes have been reported for the efficient formation of biazoles. Herein, we report a "pre-join" approach for the dehydrogenative synthesis of biazoles, which are challenging to prepare using conventional methods. A bench-stable and easily synthesized pyrazine-based group is critical for this transformation. This strategy enables the homocoupling of biazoles and the heterocoupling of two different azoles. Due to the broad substrate scope, this strategy exhibits potential for use in other fields, such as medicine, materials, and natural product chemistry.

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