Effects of Active Compounds on Placenta-mediated Pregnancy Complications

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2023 Jan 30

PMID 36711034

Authors

Jingyin Kong

SongJun Li

Yingting Li

Min Chen

Affiliations

Soon will be listed here.

Abstract

Placenta-mediated pregnancy complications (PMPCs), including preeclampsia (PE), fetal growth restriction (FGR), and recurrent spontaneous abortion (RSA), occur in approximately 5% of pregnancies and are caused by abnormal placenta development. The development of effective therapies for PMPCs is still challenging due to the complicated pathogenesis, such as disrupted vascular homeostasis and subsequent abnormal placentation. Synthetic drugs have been recommended for treating PMPCs; however, they tend to cause adverse reactions in the mother and fetus. () has potential effects on PMPCs owing to its advantages in treating cardiovascular disorders. and its active compounds could attenuate the symptoms of PMPCs through anticoagulation, vasodilation, antioxidation, and endothelial protection. Thus, in this review, we summarize the literature and provide comprehensive insights on and its phytochemical constituents, pharmacological activities, and on PMPCs, which would be valuable to explore promising drugs.

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