Construction of a Secondary Enclosure for UVB Irradiation of Mice

Overview

Journal JID Innov

Specialty Dermatology

Date 2023 Jan 27

PMID 36704704

Authors

Justin Choi

Zachary A Bordeaux

Gabriella Braun

Cole Davis

Varsha Parthasarathy

Junwen Deng

Mathew T Taylor

Anusha Kambala

Hannah Cornman

Olusola Oladipo

Martin P Alphonse

Cameron E West

Shawn G Kwatra

Madan M Kwatra

Affiliations

Soon will be listed here.

Abstract

UV irradiation is commonly used in murine models of skin cancers. Despite the popularity of using UVB rays to model photocarcinogenesis in animals, there is a lack of standardization in the secondary enclosures used to administer radiation. An appraisal of the literature also shows a general lack of details regarding the materials and procedures utilized in the fabrication of such enclosures. We present in this study a detailed overview of the construction of a UVB exposure chamber that successfully induces lesions in hairless mice. A standardized protocol for producing a UVB enclosure may reduce methodological variation in future studies seeking to investigate photocarcinogenesis in animals.

Citing Articles

Topical GZ21T Inhibits the Growth of Actinic Keratoses in a UVB-Induced Model of Skin Carcinogenesis.

Bordeaux Z, Choi J, Braun G, Davis C, Marani M, Lee K JID Innov. 2023; 3(4):100206.

PMID: 37533581 PMC: 10392087. DOI: 10.1016/j.xjidi.2023.100206.

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