Targeting and Functional Effects of Biomaterials-based Nanoagents for Acute Pancreatitis Treatment

Overview

Journal Front Bioeng Biotechnol

Date 2023 Jan 27

PMID 36704304

Authors

Yujie Cai

Qian Cao

Jiannan Li

Tongjun Liu

Affiliations

Soon will be listed here.

Abstract

Acute pancreatitis (AP) is a severe life-threatening inflammatory disease showing primary characteristics of excessive inflammatory response and oxidative stress. Based on the pathophysiology of AP, several anti-inflammatory and anti-oxidative stress agents have been studied. However, the low accumulated concentrations and scattered biodistributions limit the application of these agents. With the development of nanotechnology, functional nanomaterials can improve the bioavailability of drugs and extend their half-life by reducing immunogenicity to achieve targeted drug delivery. The biomaterial-based carriers can mediate the passive or active delivery of drugs to the target site for improved therapeutic effects, such as anti-oxidation and anti-inflammation for AP treatment. Other biomaterials-based nanomedicine may exhibit different functions with/without targeting effects. In this review, we have summarized the targeting and functional effects of biomaterials-based nanoagents specifically for AP treatment.

Citing Articles

Natural Compounds for the Treatment of Acute Pancreatitis: Novel Anti-Inflammatory Therapies.

Jiang W, Li X, Zhang Y, Zhou W Biomolecules. 2024; 14(9).

PMID: 39334867 PMC: 11430608. DOI: 10.3390/biom14091101.

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