Creep-recovery Behaviors of Articular Cartilage Under Uniaxial and Biaxial Tensile Loadings

Overview

Journal Front Bioeng Biotechnol

Date 2023 Jan 27

PMID 36704296

Authors

Lilan Gao

Gang Liu

Yansong Tan

Ruixin Li

Chunqiu Zhang

Hong Gao

Bingjie Zhao

Affiliations

Soon will be listed here.

Abstract

Creep deformation in cartilage can be observed under physiological loads in daily activities such as standing, single-leg lunge, the stance phase of gait. If not fully recovered in time, it may induce irreversible damage in cartilage and further lead to early osteoarthritis. In this study, 36 cruciform-shape samples in total from 18 bulls were employed to conduct the uniaxial and biaxial creep-recovery tests by using a biaxial cyclic testing system. Effects of stress level ( = .5, 1.0, 1.5 MPa) and biaxial stress ratio ( = 0, .3, .5, 1.0) on creep-recovery behaviors of cartilage were characterized. And then, a viscoelastic constitutive model was employed to predict its creep-recovery behaviors. The results showed that the creep strain and its three components, namely instantaneous elastic strain, delayed elastic strain and viscous flow strain, increase with the increasing stress level or with the decreasing biaxial stress ratio. Compared with uniaxial creep-recovery, biaxial creep-recovery exhibits a smaller creep strain, a faster recovery rate of creep strain and a smaller residual strain. Besides, the built viscoelastic model can be used to describe the uniaxial creep-recovery behaviors of cartilage as a good correlation between the fitted results and test results is achieved. The findings are expected to provide new insights into understanding normal joint function and cartilage pathology.

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References

Leipzig N, Athanasiou K . Unconfined creep compression of chondrocytes. J Biomech. 2004; 38(1):77-85. DOI: 10.1016/j.jbiomech.2004.03.013. View

Athanasiou K, Rosenwasser M, Buckwalter J, Malinin T, Mow V . Interspecies comparisons of in situ intrinsic mechanical properties of distal femoral cartilage. J Orthop Res. 1991; 9(3):330-40. DOI: 10.1002/jor.1100090304. View

Herberhold C, Stammberger T, Faber S, Putz R, Englmeier K, Reiser M . An MR-based technique for quantifying the deformation of articular cartilage during mechanical loading in an intact cadaver joint. Magn Reson Med. 1998; 39(5):843-50. DOI: 10.1002/mrm.1910390522. View

Roos E, Roos H, Ekdahl C, Lohmander L . Knee injury and Osteoarthritis Outcome Score (KOOS)--validation of a Swedish version. Scand J Med Sci Sports. 1998; 8(6):439-48. DOI: 10.1111/j.1600-0838.1998.tb00465.x. View

Liu F, Kozanek M, Hosseini A, Van de Velde S, Gill T, Rubash H . In vivo tibiofemoral cartilage deformation during the stance phase of gait. J Biomech. 2009; 43(4):658-65. PMC: 2823844. DOI: 10.1016/j.jbiomech.2009.10.028. View

Li L, Buschmann M, Shirazi-Adl A . Strain-rate dependent stiffness of articular cartilage in unconfined compression. J Biomech Eng. 2003; 125(2):161-8. DOI: 10.1115/1.1560142. View

Cutcliffe H, DeFrate L . Comparison of Cartilage Mechanical Properties Measured During Creep and Recovery. Sci Rep. 2020; 10(1):1547. PMC: 6994684. DOI: 10.1038/s41598-020-58220-2. View

Athanasiou K, Agarwal A, Dzida F . Comparative study of the intrinsic mechanical properties of the human acetabular and femoral head cartilage. J Orthop Res. 1994; 12(3):340-9. DOI: 10.1002/jor.1100120306. View

Eckstein F, Tieschky M, Faber S, Englmeier K, Reiser M . Functional analysis of articular cartilage deformation, recovery, and fluid flow following dynamic exercise in vivo. Anat Embryol (Berl). 1999; 200(4):419-24. DOI: 10.1007/s004290050291. View

10.

Wang H, Koff M, Potter H, Warren R, Rodeo S, Maher S . An MRI-compatible loading device to assess knee joint cartilage deformation: Effect of preloading and inter-test repeatability. J Biomech. 2015; 48(12):2934-40. DOI: 10.1016/j.jbiomech.2015.08.006. View

11.

Li J, Tsai T, Wang S, Li P, Kwon Y, Freiberg A . Prediction of in vivo knee joint kinematics using a combined dual fluoroscopy imaging and statistical shape modeling technique. J Biomech Eng. 2014; 136(12):124503. PMC: 5101023. DOI: 10.1115/1.4028819. View

12.

Chen J, Zhang J, Zhao H . Quantifying Alignment Deviations for the In-Plane Biaxial Test System via a Shape-Optimised Cruciform Specimen. Materials (Basel). 2022; 15(14). PMC: 9322858. DOI: 10.3390/ma15144949. View

13.

Si Y, Tan Y, Gao L, Li R, Zhang C, Gao H . Mechanical properties of cracked articular cartilage under uniaxial creep and cyclic tensile loading. J Biomech. 2022; 134:110988. DOI: 10.1016/j.jbiomech.2022.110988. View

14.

Wang C, Hung C, Mow V . An analysis of the effects of depth-dependent aggregate modulus on articular cartilage stress-relaxation behavior in compression. J Biomech. 2001; 34(1):75-84. DOI: 10.1016/s0021-9290(00)00137-8. View

15.

Gao L, Zhang C, Gao H, Liu Z, Xiao P . Depth and rate dependent mechanical behaviors for articular cartilage: experiments and theoretical predictions. Mater Sci Eng C Mater Biol Appl. 2014; 38:244-51. DOI: 10.1016/j.msec.2014.02.009. View

16.

Erisken C, Kalyon D, Wang H . Functionally graded electrospun polycaprolactone and beta-tricalcium phosphate nanocomposites for tissue engineering applications. Biomaterials. 2008; 29(30):4065-73. DOI: 10.1016/j.biomaterials.2008.06.022. View

17.

Kamalanathan S, Broom N . The biomechanical ambiguity of the articular surface. J Anat. 1993; 183 ( Pt 3):567-78. PMC: 1259882. View

18.

Hosseini A, Van de Velde S, Kozanek M, Gill T, Grodzinsky A, Rubash H . In-vivo time-dependent articular cartilage contact behavior of the tibiofemoral joint. Osteoarthritis Cartilage. 2010; 18(7):909-16. PMC: 2900485. DOI: 10.1016/j.joca.2010.04.011. View

19.

Gao L, Liu D, Gao H, Lv L, Zhang C . Effects of creep and creep-recovery on ratcheting strain of articular cartilage under cyclic compression. Mater Sci Eng C Mater Biol Appl. 2018; 94:988-997. DOI: 10.1016/j.msec.2018.10.047. View

20.

Chan D, Cai L, Butz K, Trippel S, Nauman E, Neu C . In vivo articular cartilage deformation: noninvasive quantification of intratissue strain during joint contact in the human knee. Sci Rep. 2016; 6:19220. PMC: 4707486. DOI: 10.1038/srep19220. View