The Combined Effect of Nanobubble-IR783-HPPH-Affibody Complex and Laser on HER2-Positive Breast Cancer

Overview

Journal Int J Nanomedicine

Publisher Dove Medical Press

Specialty Biotechnology

Date 2023 Jan 27

PMID 36703724

Authors

Wenbin Cai

Wei Lv

Li Meng

Yunyou Duan

Li Zhang

Affiliations

Soon will be listed here.

Abstract

Introduction: Nanobubble is an innovative ultrasound contrast agent that triggers the development of targeted imaging of HER2-positive breast cancer by combining with HER2 affibody and IR783. HPPH is a second-generation photosensitiser that is effective in treating tumours. Hence, the nanobubble-IR783-HPPH-affibody (NIHA) complex demonstrates considerable potential in the treatment of HER2-positive breast cancer.

Methods: We fabricated the NIHA complex via an advanced thin-film hydration method and detected its characteristics such as particle size, morphology, stability, and cytotoxicity. Moreover, the effect of NIHA complex with laser on HER2-positive breast cancer was confirmed via in vitro and in vivo experiments.

Results: The NIHA complex was spheroid, stable and exhibited no cytotoxicity; moreover, its particle size was 524.8 ± 53.3 nm (n = 5). In combination with laser treatment, NIHA complex reduced the cell viability and tumour volume, induced apoptosis of HER2-positive breast cancer cells, and prolonged survival of nude mice.

Conclusion: The newly prepared NIHA complex with laser treatment has the potential on treating HER2-positive breast cancer.

Citing Articles

Construction of a Tumor-Targeting Nanobubble with Multiple Scattering Interfaces and its Enhancement of Ultrasound Imaging.

Ma Z, Zhang Y, Zhu Y, Cui M, Liu Y, Duan Y Int J Nanomedicine. 2024; 19:4651-4665.

PMID: 38799698 PMC: 11128256. DOI: 10.2147/IJN.S462917.

Effects of polymer terminal group inside micelle core on paclitaxel loading promoting and burst release suppressing.

He H, Huang N, Qiu Z, He L, Guo J, Xu M J Gastrointest Oncol. 2023; 14(4):1659-1668.

PMID: 37720454 PMC: 10502554. DOI: 10.21037/jgo-23-206.

References

Fang J, Nakamura H, Maeda H . The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. Adv Drug Deliv Rev. 2010; 63(3):136-51. DOI: 10.1016/j.addr.2010.04.009. View

Yang X, Zhu B, Dong T, Pan P, Shuai X, Inoue Y . Interactions between an anticancer drug and polymeric micelles based on biodegradable polyesters. Macromol Biosci. 2008; 8(12):1116-25. DOI: 10.1002/mabi.200800085. View

Oeffinger B, Wheatley M . Development and characterization of a nano-scale contrast agent. Ultrasonics. 2004; 42(1-9):343-7. DOI: 10.1016/j.ultras.2003.11.011. View

Prabhakar A, Banerjee R . Nanobubble Liposome Complexes for Diagnostic Imaging and Ultrasound-Triggered Drug Delivery in Cancers: A Theranostic Approach. ACS Omega. 2019; 4(13):15567-15580. PMC: 6761614. DOI: 10.1021/acsomega.9b01924. View

Zhou T, Cai W, Yang H, Zhang H, Hao M, Yuan L . Annexin V conjugated nanobubbles: A novel ultrasound contrast agent for in vivo assessment of the apoptotic response in cancer therapy. J Control Release. 2018; 276:113-124. DOI: 10.1016/j.jconrel.2018.03.008. View

Bray F, Ferlay J, Soerjomataram I, Siegel R, Torre L, Jemal A . Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018; 68(6):394-424. DOI: 10.3322/caac.21492. View

Lv W, Shen Y, Yang H, Yang R, Cai W, Zhang J . A Novel Bimodal Imaging Agent Targeting HER2 Molecule of Breast Cancer. J Immunol Res. 2018; 2018:6202876. PMC: 5944285. DOI: 10.1155/2018/6202876. View

Menendez J, Papadimitropoulou A, Steen T, Cuyas E, Oza-Gajera B, Verdura S . Fatty Acid Synthase Confers Tamoxifen Resistance to ER+/HER2+ Breast Cancer. Cancers (Basel). 2021; 13(5). PMC: 7961649. DOI: 10.3390/cancers13051132. View

. Vemurafenib in Multiple Nonmelanoma Cancers with BRAF V600 Mutations; Adjuvant Pertuzumab and Trastuzumab in Early HER2-Positive Breast Cancer. N Engl J Med. 2018; 379(16):1585. View

10.

Yin L, Wang Z . Roles of the ER-α36-EGFR/HER2 positive regulatory loops in tamoxifen resistance. Steroids. 2016; 111:95-99. DOI: 10.1016/j.steroids.2016.01.019. View

11.

Wang Z, Zhang F, Shao D, Chang Z, Wang L, Hu H . Janus Nanobullets Combine Photodynamic Therapy and Magnetic Hyperthermia to Potentiate Synergetic Anti-Metastatic Immunotherapy. Adv Sci (Weinh). 2019; 6(22):1901690. PMC: 6864517. DOI: 10.1002/advs.201901690. View

12.

Yin T, Wang P, Li J, Wang Y, Zheng B, Zheng R . Tumor-penetrating codelivery of siRNA and paclitaxel with ultrasound-responsive nanobubbles hetero-assembled from polymeric micelles and liposomes. Biomaterials. 2014; 35(22):5932-43. DOI: 10.1016/j.biomaterials.2014.03.072. View

13.

Santiago Franco M, Gomes E, Roque M, Oliveira M . Triggered Drug Release From Liposomes: Exploiting the Outer and Inner Tumor Environment. Front Oncol. 2021; 11:623760. PMC: 8008067. DOI: 10.3389/fonc.2021.623760. View

14.

Bellnier D, Greco W, Loewen G, Nava H, Oseroff A, Pandey R . Population pharmacokinetics of the photodynamic therapy agent 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a in cancer patients. Cancer Res. 2003; 63(8):1806-13. View

15.

Hobbs S, Monsky W, Yuan F, ROBERTS W, Griffith L, Torchilin V . Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proc Natl Acad Sci U S A. 1998; 95(8):4607-12. PMC: 22537. DOI: 10.1073/pnas.95.8.4607. View

16.

Dai J, Zou S, Pei Y, Cheng D, Ai H, Shuai X . Polyethylenimine-grafted copolymer of poly(l-lysine) and poly(ethylene glycol) for gene delivery. Biomaterials. 2010; 32(6):1694-705. DOI: 10.1016/j.biomaterials.2010.10.044. View

17.

Abou-Elkacem L, Bachawal S, Willmann J . Ultrasound molecular imaging: Moving toward clinical translation. Eur J Radiol. 2015; 84(9):1685-93. PMC: 4545409. DOI: 10.1016/j.ejrad.2015.03.016. View

18.

Dobson J, de Queiroz G, Golding J . Photodynamic therapy and diagnosis: Principles and comparative aspects. Vet J. 2018; 233:8-18. DOI: 10.1016/j.tvjl.2017.11.012. View

19.

Chen C, Yang C, Chen Y, Shih C, Lo S, Lin C . Decreased expression of stomatin predicts poor prognosis in HER2-positive breast cancer. BMC Cancer. 2016; 16:697. PMC: 5006529. DOI: 10.1186/s12885-016-2681-7. View

20.

Yang H, Cai W, Xu L, Lv X, Qiao Y, Li P . Nanobubble-Affibody: Novel ultrasound contrast agents for targeted molecular ultrasound imaging of tumor. Biomaterials. 2014; 37:279-88. DOI: 10.1016/j.biomaterials.2014.10.013. View