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Design, Synthesis and Applications of Responsive Macrocycles

Overview
Journal Commun Chem
Publisher Springer Nature
Specialty Chemistry
Date 2023 Jan 27
PMID 36703444
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Abstract

Inspired by the lock and key principle, the development of supramolecular macrocyclic chemistry has promoted the prosperous growth of host-guest chemistry. The updated induced-fit and conformation selection model spurred the emerging research on responsive macrocycles (RMs). This review introduces RMs, covering their design, synthesis and applications. It gives readers insight into the dynamic control of macrocyclic molecules and the exploration of materials with desired functions.

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References
1.
Pinalli R, Pedrini A, Dalcanale E . Biochemical sensing with macrocyclic receptors. Chem Soc Rev. 2018; 47(18):7006-7026. DOI: 10.1039/c8cs00271a. View

2.
van Dijken D, Kovaricek P, Ihrig S, Hecht S . Acylhydrazones as Widely Tunable Photoswitches. J Am Chem Soc. 2015; 137(47):14982-91. DOI: 10.1021/jacs.5b09519. View

3.
Erbas-Cakmak S, Fielden S, Karaca U, Leigh D, McTernan C, Tetlow D . Rotary and linear molecular motors driven by pulses of a chemical fuel. Science. 2017; 358(6361):340-343. DOI: 10.1126/science.aao1377. View

4.
Zhang Y, Zheng X, Cao N, Yang C, Li H . A Kinetically Stable Macrocycle Self-Assembled in Water. Org Lett. 2018; 20(8):2356-2359. DOI: 10.1021/acs.orglett.8b00693. View

5.
Marsault E, Peterson M . Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery. J Med Chem. 2011; 54(7):1961-2004. DOI: 10.1021/jm1012374. View