Transferrin Receptor 1: Keeper of HFE

Overview

Journal Blood

Publisher Elsevier

Specialty Hematology

Date 2023 Jan 26

PMID 36701171

Authors

Nermi L Parrow

Robert E Fleming

Affiliations

Soon will be listed here.

References

Goswami T, Andrews N . Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing. J Biol Chem. 2006; 281(39):28494-8. DOI: 10.1074/jbc.C600197200. View

Wu X, Wang Y, Wu Q, Cheng W, Liu W, Zhao Y . HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression. Blood. 2014; 124(8):1335-43. PMC: 4624447. DOI: 10.1182/blood-2014-01-552281. View

Schmidt P, Toran P, Giannetti A, Bjorkman P, Andrews N . The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression. Cell Metab. 2008; 7(3):205-14. PMC: 2292811. DOI: 10.1016/j.cmet.2007.11.016. View

Schmidt P, Fleming M . Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2. Am J Hematol. 2012; 87(6):588-95. PMC: 3386558. DOI: 10.1002/ajh.23173. View

Fillebeen C, Charlebois E, Wagner J, Katsarou A, Mui J, Vali H . Transferrin receptor 1 controls systemic iron homeostasis by fine-tuning hepcidin expression to hepatocellular iron load. Blood. 2018; 133(4):344-355. DOI: 10.1182/blood-2018-05-850404. View

Gao J, Zhao N, Knutson M, Enns C . The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 cells. J Biol Chem. 2008; 283(31):21462-8. PMC: 2490774. DOI: 10.1074/jbc.M803150200. View

Wallace D, Summerville L, Subramaniam V . Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload. Gastroenterology. 2007; 132(1):301-10. DOI: 10.1053/j.gastro.2006.11.028. View

Xiao X, Moschetta G, Xu Y, Fisher A, Alfaro-Magallanes V, Dev S . Regulation of iron homeostasis by hepatocyte TfR1 requires HFE and contributes to hepcidin suppression in β-thalassemia. Blood. 2022; 141(4):422-432. PMC: 9936306. DOI: 10.1182/blood.2022017811. View

Wallace D, Summerville L, Crampton E, Frazer D, Anderson G, Subramaniam V . Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload. Hepatology. 2009; 50(6):1992-2000. DOI: 10.1002/hep.23198. View

10.

Parrow N, Li Y, Feola M, Guerra A, Casu C, Prasad P . Lobe specificity of iron binding to transferrin modulates murine erythropoiesis and iron homeostasis. Blood. 2019; 134(17):1373-1384. PMC: 6839954. DOI: 10.1182/blood.2018893099. View