Ameliorative Effect of Taurine Against Diabetes and Renal-associated Disorders (Review)

Overview

Journal Med Int (Lond)

Publisher Spandidos Publications

Specialty General Medicine

Date 2023 Jan 26

PMID 36699147

Authors

Stella Baliou

Maria Adamaki

Petros Ioannou

Aglaia Pappa

Mihalis I Panayiotidis

Ioannis Christodoulou

Demetrios A Spandidos

Anthony M Kyriakopoulos

Vassilis Zoumpourlis

Affiliations

Soon will be listed here.

Abstract

To develop novel therapeutic methods for both diabetic and renal disorders, scientists had initially focused on elucidating the molecular mechanisms of taurine in established cell lines and mouse models. Although a large amount of data have been revealed, taurine has been confirmed to be the next step of novel promising therapeutic interventions against diabetic disorders. Taurine appears to ameliorate diabetes 1-related complications in various organs through its antioxidant, anti-inflammatory and anti-hormonal actions. In type 2 diabetes, taurine has been positively implicated in glucose homeostasis, exerting potent hypoglycemic, anti-obesity, hypotensive and hypolipidemic effects. Of particular interest is that taurine provides protection against renal dysfunction, including hypertension and proteinuria, specific glomerular and tubular disorders, acute and chronic renal conditions, and diabetic nephropathy. The ameliorative effects of taurine against renal disorders are based on its osmoregulatory properties, its association with signaling pathways and its association with the renin-angiotensin-aldosterone system (RAAS). Further clinical studies are required to ensure the importance of research findings.

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