Gut Microbiota and Microbiota-based Therapies for Infection

Overview

Journal Front Med (Lausanne)

Specialty General Medicine

Date 2023 Jan 26

PMID 36698844

Authors

Teena Chopra

Gail Hecht

Glenn Tillotson

Affiliations

Soon will be listed here.

Abstract

infection poses significant clinical challenges due to its recurrent nature. Current antibiotic management does not address the underlying issue, that of a disturbed gastrointestinal microbiome, called dysbiosis. This provides a supportive environment for the germination of spores which lead to infection and toxin production as well as an array of other health conditions. The use of microbiome restoration therapies such as live biotherapeutics can reverse dysbiosis and lead to good clinical outcomes. Several such therapies are under clinical investigation.

Citing Articles

Can the Evidence-Based Use of Probiotics (Notably Saccharomyces boulardii CNCM I-745 and Lactobacillus rhamnosus GG) Mitigate the Clinical Effects of Antibiotic-Associated Dysbiosis?.

Waitzberg D, Guarner F, Hojsak I, Ianiro G, Polk D, Sokol H Adv Ther. 2024; 41(3):901-914.

PMID: 38286962 PMC: 10879266. DOI: 10.1007/s12325-024-02783-3.

Tunable control of abundance and gut metabolites by co-administration of human milk oligosaccharides.

Reens A, Cosetta C, Saur R, Trofimuk O, Brooker S, Lee M Gut Microbes. 2024; 16(1):2304160.

PMID: 38235736 PMC: 10798361. DOI: 10.1080/19490976.2024.2304160.

Microbial ecology between and gut microbiota.

Kamiya S Biosci Microbiota Food Health. 2023; 42(4):229-235.

PMID: 37791342 PMC: 10542429. DOI: 10.12938/bmfh.2023-033.

, a New "Superbug".

Markovska R, Dimitrov G, Gergova R, Boyanova L Microorganisms. 2023; 11(4).

PMID: 37110267 PMC: 10140992. DOI: 10.3390/microorganisms11040845.

References

Desai K, Gupta S, Dubberke E, Prabhu V, Browne C, Mast T . Epidemiological and economic burden of Clostridium difficile in the United States: estimates from a modeling approach. BMC Infect Dis. 2016; 16:303. PMC: 4912810. DOI: 10.1186/s12879-016-1610-3. View

Brown K, Khanafer N, Daneman N, Fisman D . Meta-analysis of antibiotics and the risk of community-associated Clostridium difficile infection. Antimicrob Agents Chemother. 2013; 57(5):2326-32. PMC: 3632900. DOI: 10.1128/AAC.02176-12. View

Rodrigues R, Barber G, Ananthakrishnan A . A Comprehensive Study of Costs Associated With Recurrent Clostridium difficile Infection. Infect Control Hosp Epidemiol. 2016; 38(2):196-202. DOI: 10.1017/ice.2016.246. View

Leffler D, Lamont J . Clostridium difficile infection. N Engl J Med. 2015; 372(16):1539-48. DOI: 10.1056/NEJMra1403772. View

Collins C, Ayturk M, Flahive J, Emhoff T, Anderson Jr F, Santry H . Epidemiology and outcomes of community-acquired Clostridium difficile infections in Medicare beneficiaries. J Am Coll Surg. 2014; 218(6):1141-1147.e1. PMC: 4412342. DOI: 10.1016/j.jamcollsurg.2014.01.053. View

Khanna S, Gupta A, Baddour L, Pardi D . Epidemiology, outcomes, and predictors of mortality in hospitalized adults with Clostridium difficile infection. Intern Emerg Med. 2015; 11(5):657-65. DOI: 10.1007/s11739-015-1366-6. View

Cheng Y, Phelps E, Nemes S, Rogers N, Sagi S, Bohm M . Fecal Microbiota Transplant Decreases Mortality in Patients with Refractory Severe or Fulminant Clostridioides difficile Infection. Clin Gastroenterol Hepatol. 2020; 18(10):2234-2243.e1. DOI: 10.1016/j.cgh.2019.12.029. View

Balsells E, Shi T, Leese C, Lyell I, Burrows J, Wiuff C . Global burden of infections: a systematic review and meta-analysis. J Glob Health. 2019; 9(1):010407. PMC: 6304170. DOI: 10.7189/jogh.09.010407. View

Eze P, Balsells E, Kyaw M, Nair H . Risk factors for infections - an overview of the evidence base and challenges in data synthesis. J Glob Health. 2017; 7(1):010417. PMC: 5460399. DOI: 10.7189/jogh.07.010417. View

10.

Shin A, Preidis G, Shulman R, Kashyap P . The Gut Microbiome in Adult and Pediatric Functional Gastrointestinal Disorders. Clin Gastroenterol Hepatol. 2018; 17(2):256-274. PMC: 6314902. DOI: 10.1016/j.cgh.2018.08.054. View

11.

Wexler H . Bacteroides: the good, the bad, and the nitty-gritty. Clin Microbiol Rev. 2007; 20(4):593-621. PMC: 2176045. DOI: 10.1128/CMR.00008-07. View

12.

Bafeta A, Yavchitz A, Riveros C, Batista R, Ravaud P . Methods and Reporting Studies Assessing Fecal Microbiota Transplantation: A Systematic Review. Ann Intern Med. 2017; 167(1):34-39. DOI: 10.7326/M16-2810. View

13.

Brown K, Langford B, Schwartz K, Diong C, Garber G, Daneman N . Antibiotic Prescribing Choices and Their Comparative C. Difficile Infection Risks: A Longitudinal Case-Cohort Study. Clin Infect Dis. 2020; 72(5):836-844. PMC: 7935390. DOI: 10.1093/cid/ciaa124. View

14.

Bhalodi A, van Engelen T, Virk H, Wiersinga W . Impact of antimicrobial therapy on the gut microbiome. J Antimicrob Chemother. 2019; 74(Suppl 1):i6-i15. PMC: 6382031. DOI: 10.1093/jac/dky530. View

15.

Song J, Kim Y . Recurrent Infection: Risk Factors, Treatment, and Prevention. Gut Liver. 2018; 13(1):16-24. PMC: 6346998. DOI: 10.5009/gnl18071. View

16.

Segal J, Mullish B, Quraishi M, Iqbal T, Marchesi J, Sokol H . Mechanisms underpinning the efficacy of faecal microbiota transplantation in treating gastrointestinal disease. Therap Adv Gastroenterol. 2020; 13:1756284820946904. PMC: 7475788. DOI: 10.1177/1756284820946904. View

17.

Falcone M, Russo A, Iraci F, Carfagna P, Goldoni P, Vullo V . Risk Factors and Outcomes for Bloodstream Infections Secondary to Clostridium difficile Infection. Antimicrob Agents Chemother. 2015; 60(1):252-7. PMC: 4704211. DOI: 10.1128/AAC.01927-15. View

18.

McGovern B, Ford C, Henn M, Pardi D, Khanna S, Hohmann E . SER-109, an Investigational Microbiome Drug to Reduce Recurrence After Clostridioides difficile Infection: Lessons Learned From a Phase 2 Trial. Clin Infect Dis. 2020; 72(12):2132-2140. PMC: 8204772. DOI: 10.1093/cid/ciaa387. View

19.

Davies K, Lawrence J, Berry C, Davis G, Yu H, Cai B . Risk Factors for Primary Infection; Results From the Observational Study of Risk Factors for Infection in Hospitalized Patients With Infective Diarrhea (ORCHID). Front Public Health. 2020; 8:293. PMC: 7379483. DOI: 10.3389/fpubh.2020.00293. View

20.

Donskey C . Clostridium difficile in Older Adults. Infect Dis Clin North Am. 2017; 31(4):743-756. DOI: 10.1016/j.idc.2017.07.003. View