The Hematopoietic Potential Of methanolic and Aqueous Extracts of in a Phenylhydrazine Model of Anemia

Overview

Journal Avicenna J Phytomed

Publisher Mashhad University of Medical Sciences

Date 2023 Jan 26

PMID 36698739

Authors

Kobra Shirani

Bamdad Riahi-Zanjani

Seyed Navid Omidkhoda

Samira Barangi

Gholamreza Karimi

Affiliations

Soon will be listed here.

Abstract

Objective: , commonly known as Purslane, is traditionally used as a sour, diuretic, and cooling herb with hemostatic properties. The present study evaluates the antianemic effect of methanolic and aqueous extracts of in a phenylhydrazine model of anemia.

Materials And Methods: Phenylhydrazine (60 mg/kg/day, i.p., two consecutive days) was used to induce anemia in rats. The aqueous and methanolic extracts of were prepared, and three methods of treatment were defined with two doses (500 and 750 mg/kg, i.p.). The hematological parameters and blood cell morphology, total and direct bilirubin, and morphology, and pathology of bone marrow were evaluated.

Results: The results showed that the methanolic extract has better effects than aqueous extract in improving phenylhydrazine-induced anemia. Our results showed that administration of 500 and 750 mg/kg of methanolic extracts for 4 days could protect against the development of anemia caused by phenylhydrazine.

Conclusion: In summary, the methanolic extracts of might be effective in phenylhydrazine-induced anemia.

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