Diffuse Reflection Spectroscopy at the Fingertip: Design and Performance of a Compact Side-firing Probe for Tissue Discrimination During Colorectal Cancer Surgery

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2023 Jan 26

PMID 36698675

Authors

Freija Geldof

Mark Witteveen

Henricus J C M Sterenborg

Theo J M Ruers

Behdad Dashtbozorg

Affiliations

Soon will be listed here.

Abstract

Optical technologies are widely used for tissue sensing purposes. However, maneuvering conventional probe designs with flat-tipped fibers in narrow spaces can be challenging, for instance during pelvic colorectal cancer surgery. In this study, a compact side-firing fiber probe was developed for tissue discrimination during colorectal cancer surgery using diffuse reflectance spectroscopy. The optical behavior was compared to flat-tipped fibers using both Monte Carlo simulations and experimental phantom measurements. The tissue classification performance was examined using freshly excised colorectal cancer specimens. Using the developed probe and classification algorithm, an accuracy of 0.92 was achieved for discriminating tumor tissue from healthy tissue.

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References

Baltussen E, Snaebjornsson P, de Koning S, Sterenborg H, Aalbers A, Kok N . Diffuse reflectance spectroscopy as a tool for real-time tissue assessment during colorectal cancer surgery. J Biomed Opt. 2017; 22(10):1-6. DOI: 10.1117/1.JBO.22.10.106014. View

Baltussen E, Sterenborg H, Ruers T, Dashtbozorg B . Optimizing algorithm development for tissue classification in colorectal cancer based on diffuse reflectance spectra. Biomed Opt Express. 2019; 10(12):6096-6113. PMC: 6913395. DOI: 10.1364/BOE.10.006096. View

Jacques S . Optical properties of biological tissues: a review. Phys Med Biol. 2013; 58(11):R37-61. DOI: 10.1088/0031-9155/58/11/R37. View

Langhout G, Spliethoff J, Schmitz S, Aalbers A, van Velthuysen M, Hendriks B . Differentiation of healthy and malignant tissue in colon cancer patients using optical spectroscopy: A tool for image-guided surgery. Lasers Surg Med. 2015; 47(7):559-565. DOI: 10.1002/lsm.22388. View

Yu B, Shah A, Wang B, Rajaram N, Wang Q, Ramanujam N . Measuring tumor cycling hypoxia and angiogenesis using a side-firing fiber optic probe. J Biophotonics. 2012; 7(7):552-64. PMC: 3702687. DOI: 10.1002/jbio.201200187. View

Yu B, Burnside E, Sisney G, Harter J, Zhu C, Dhalla A . Feasibility of near-infrared diffuse optical spectroscopy on patients undergoing imageguided core-needle biopsy. Opt Express. 2009; 15(12):7335-50. PMC: 2801922. DOI: 10.1364/oe.15.007335. View

Baran T, Fenn M, Foster T . Determination of optical properties by interstitial white light spectroscopy using a custom fiber optic probe. J Biomed Opt. 2013; 18(10):107007. PMC: 3805060. DOI: 10.1117/1.JBO.18.10.107007. View

Orosco R, Tapia V, Califano J, Clary B, Cohen E, Kane C . Positive Surgical Margins in the 10 Most Common Solid Cancers. Sci Rep. 2018; 8(1):5686. PMC: 5890246. DOI: 10.1038/s41598-018-23403-5. View

Fang Q, Yan S . Graphics processing unit-accelerated mesh-based Monte Carlo photon transport simulations. J Biomed Opt. 2019; 24(11):1-6. PMC: 6863969. DOI: 10.1117/1.JBO.24.11.115002. View

10.

Basij M, Yan Y, Alshahrani S, Helmi H, Burton T, Burmeister J . Miniaturized phased-array ultrasound and photoacoustic endoscopic imaging system. Photoacoustics. 2019; 15:100139. PMC: 6677929. DOI: 10.1016/j.pacs.2019.100139. View

11.

Ong Y, Dimofte A, Kim M, Finlay J, Sheng T, Singhal S . Reactive Oxygen Species Explicit Dosimetry for Photofrin-mediated Pleural Photodynamic Therapy. Photochem Photobiol. 2019; 96(2):340-348. PMC: 7299188. DOI: 10.1111/php.13176. View

12.

Giglia M, Stein S . Overlooked Long-Term Complications of Colorectal Surgery. Clin Colon Rectal Surg. 2019; 32(3):204-211. PMC: 6494605. DOI: 10.1055/s-0038-1677027. View

13.

Utzinger U, Richards-Kortum R . Fiber optic probes for biomedical optical spectroscopy. J Biomed Opt. 2003; 8(1):121-47. DOI: 10.1117/1.1528207. View

14.

Lundby L, Duelund-Jakobsen J . Management of fecal incontinence after treatment for rectal cancer. Curr Opin Support Palliat Care. 2010; 5(1):60-4. DOI: 10.1097/SPC.0b013e3283435dd4. View

15.

Karpiouk A, Wang B, Emelianov S . Development of a catheter for combined intravascular ultrasound and photoacoustic imaging. Rev Sci Instrum. 2010; 81(1):014901. PMC: 2814830. DOI: 10.1063/1.3274197. View

16.

Gardner A, Hayakawa C, Venugopalan V . Coupled forward-adjoint Monte Carlo simulation of spatial-angular light fields to determine optical sensitivity in turbid media. J Biomed Opt. 2014; 19(6):065003. PMC: 4073599. DOI: 10.1117/1.JBO.19.6.065003. View

17.

Attaallah W, Ertekin C, Tinay I, Yegen C . High rate of sexual dysfunction following surgery for rectal cancer. Ann Coloproctol. 2014; 30(5):210-5. PMC: 4213936. DOI: 10.3393/ac.2014.30.5.210. View

18.

Nagtegaal I, Quirke P . What is the role for the circumferential margin in the modern treatment of rectal cancer?. J Clin Oncol. 2008; 26(2):303-12. DOI: 10.1200/JCO.2007.12.7027. View

19.

Sung H, Ferlay J, Siegel R, Laversanne M, Soerjomataram I, Jemal A . Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021; 71(3):209-249. DOI: 10.3322/caac.21660. View

20.

Zonios G, Perelman L, Backman V, Manoharan R, Fitzmaurice M, van Dam J . Diffuse reflectance spectroscopy of human adenomatous colon polyps in vivo. Appl Opt. 2008; 38(31):6628-37. DOI: 10.1364/ao.38.006628. View