» Articles » PMID: 36698659

Twenty-five Years of Clinical Applications Using Adaptive Optics Ophthalmoscopy [Invited]

Overview
Specialty Radiology
Date 2023 Jan 26
PMID 36698659
Authors
Affiliations
Soon will be listed here.
Abstract

Twenty-five years ago, adaptive optics (AO) was combined with fundus photography, thereby initiating a new era in the field of ophthalmic imaging. Since that time, clinical applications of AO ophthalmoscopy to investigate visual system structure and function in both health and disease abound. To date, AO ophthalmoscopy has enabled visualization of most cell types in the retina, offered insight into retinal and systemic disease pathogenesis, and been integrated into clinical trials. This article reviews clinical applications of AO ophthalmoscopy and addresses remaining challenges for AO ophthalmoscopy to become fully integrated into standard ophthalmic care.

Citing Articles

The Perspective of Using Optical Coherence Tomography in Ophthalmology: Present and Future Applications.

Vasilescu M, Macovei M Diagnostics (Basel). 2025; 15(4).

PMID: 40002553 PMC: 11854452. DOI: 10.3390/diagnostics15040402.


From Cellular to Metabolic: Advances in Imaging of Inherited Retinal Diseases.

Parameswarappa D, Kulkarni A, Sahoo N, Padhy S, Singh S, Heon E Diagnostics (Basel). 2025; 15(1.

PMID: 39795556 PMC: 11720060. DOI: 10.3390/diagnostics15010028.


Ultrafast adaptive optics for imaging the living human eye.

Liu Y, Crowell J, Kurokawa K, Bernucci M, Ji Q, Lassoued A Nat Commun. 2024; 15(1):10409.

PMID: 39613735 PMC: 11607088. DOI: 10.1038/s41467-024-54687-z.


Editorial: Advances in optical imaging for ophthalmology: new developments, clinical applications and perspectives.

Mece P, Gocho K, Harmening W, Rossi E, Young L Front Ophthalmol (Lausanne). 2024; 4:1496015.

PMID: 39479555 PMC: 11521964. DOI: 10.3389/fopht.2024.1496015.


Biometry study of foveal isoplanatic patch variation for adaptive optics retinal imaging.

Huang X, Hargrave A, Bentley J, Dubra A Biomed Opt Express. 2024; 15(10):5674-5690.

PMID: 39421787 PMC: 11482173. DOI: 10.1364/BOE.536645.


References
1.
Takagi S, Mandai M, Gocho K, Hirami Y, Yamamoto M, Fujihara M . Evaluation of Transplanted Autologous Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium in Exudative Age-Related Macular Degeneration. Ophthalmol Retina. 2019; 3(10):850-859. DOI: 10.1016/j.oret.2019.04.021. View

2.
Hasegawa T, Ooto S, Akagi T, Kameda T, Nakanishi H, Ikeda H . Expansion of retinal nerve fiber bundle narrowing in glaucoma: An adaptive optics scanning laser ophthalmoscopy study. Am J Ophthalmol Case Rep. 2020; 19:100732. PMC: 7225615. DOI: 10.1016/j.ajoc.2020.100732. View

3.
Jackson K, Vergilio G, Cooper R, Ying G, Morgan J . A 2-Year Longitudinal Study of Normal Cone Photoreceptor Density. Invest Ophthalmol Vis Sci. 2019; 60(5):1420-1430. PMC: 6736277. DOI: 10.1167/iovs.18-25904. View

4.
Choi S, Zawadzki R, Lim M, Brandt J, Keltner J, Doble N . Evidence of outer retinal changes in glaucoma patients as revealed by ultrahigh-resolution in vivo retinal imaging. Br J Ophthalmol. 2010; 95(1):131-41. PMC: 3020908. DOI: 10.1136/bjo.2010.183756. View

5.
Legras R, Gaudric A, Woog K . Distribution of cone density, spacing and arrangement in adult healthy retinas with adaptive optics flood illumination. PLoS One. 2018; 13(1):e0191141. PMC: 5770065. DOI: 10.1371/journal.pone.0191141. View