The Influence of Different Glucose Tolerance on QTc Interval: a Population-based Study

Overview

Journal BMC Cardiovasc Disord

Publisher Biomed Central

Specialty Cardiology & Vascular Diseases

Date 2023 Jan 25

PMID 36698056

Authors

Ning Lin

Hongmei Zhang

Xiaoyong Li

Yixin Niu

Hongxia Gu

Shuai Lu

Zhen Yang

Qing Su

Li Qin

Affiliations

Soon will be listed here.

Abstract

Background: Corrected QT (QTc) interval has been reported to be associated with type 2 diabetes. This study aimed to explore the relationship between different glucose tolerance and QTc intervals among middle-aged and older Chinese individuals.

Methods: We conducted a cross-sectional analysis that included 9898 subjects (3194 men and 6704 women) in a Chinese population. Glucose tolerance was studied during the oral glucose tolerance test (OGTT). Insulin, blood pressure, hemoglobin A1c (HbA1c), serum lipids, hepatic transaminases and waist-to-hip ratio were assessed. The QTc interval was derived from ECG recordings, and the subjects were stratified based on different glucose tolerance.

Results: QTc interval levels were increased significantly in the subjects with abnormal glucose metabolism compared with the normal glucose regulation group. Multiple regression analyses showed that the QTc interval was significantly associated with fasting plasma glucose, 2-h OGTT plasma glucose and HbA1c. The odds ratio of prolonged QTc was 1.396 for impaired glucose regulation (IFG)/impaired fasting glucose (IGT) (95% CI 0.126-1.730), and 1.342 for type 2 diabetes (95% CI 0.142-1.577) after all potential confounders were adjusted.

Conclusions: Impaired glucose tolerance (IGR) and diabetes are associated with prolonged QTc intervals among middle-aged and older Chinese individuals. Abnormal glucose regulation can be used to monitor the QTc interval in the population.

Citing Articles

Exploring electrocardiographic alterations and the prolongation of QT interval in patients with diabetes mellitus.

Arya T, Kumar R, Aziz T, Alam M, Kujur A J Family Med Prim Care. 2024; 13(11):5033-5039.

PMID: 39723001 PMC: 11668398. DOI: 10.4103/jfmpc.jfmpc_747_24.

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