C-methionine PET Imaging Characteristics in Children with Diffuse Intrinsic Pontine Gliomas and Relationship to Survival and H3 K27M Mutation Status

Overview

Journal Eur J Nucl Med Mol Imaging

Specialties Biophysics
Nuclear Medicine
Radiology

Date 2023 Jan 25

PMID 36697961

Authors

Xiaobin Zhao

Deling Li

Zhen Qiao

Kai Wang

Qian Chen

Changcun Pan

Yuliang Wu

Dan Xiao

Tianshu Xi

Liwei Zhang

Lin Ai

Affiliations

Soon will be listed here.

Abstract

Purpose: This study aimed to describe C-methionine (C-MET) PET imaging characteristics in patients with paediatric diffuse intrinsic pontine glioma (DIPG) and correlate them with survival and H3 K27M mutation status.

Methods: We retrospectively analysed 98 children newly diagnosed with DIPG who underwent C-MET PET. PET imaging characteristics evaluated included uptake intensity, uniformity, metabolic tumour volume (MTV), and total lesion methionine uptake (TLMU). The maximum, mean, and peak of the tumour-to-background ratio (TBR), calculated as the corresponding standardised uptake values (SUV) divided by the mean reference value, were also recorded. The associations between the PET imaging characteristics and clinical outcomes in terms of progression-free survival (PFS) and overall survival (OS) and H3 K27M mutation status were assessed, respectively.

Results: In univariate analysis, imaging characteristics significantly associated with shorter PFS and OS included a higher uniformity grade, higher TBRs, larger MTV, and higher TLMU. In multivariate analysis, larger MTV at diagnosis, shorter symptom duration, and no treatment were significantly correlated with shorter PFS and OS. The PET imaging features were not correlated with H3 K27M mutation status.

Conclusion: Although several imaging features were significantly associated with PFS and OS, only MTV, indicating the size of the active tumour, was identified as a strong independent prognostic factor.

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