Reliability and Validity of the Chinese Version of Chronic Liver Disease Questionnaire-nonalcoholic Fatty Liver Disease in Patients with Nonalcoholic Fatty Liver Disease: a Multicenter Cross-sectional Survey in China

Overview

Journal Qual Life Res

Specialties Pharmacology
Rehabilitation Medicine

Date 2023 Jan 24

PMID 36692593

Authors

Rui Huang

Jian-Gao Fan

Jun-Ping Shi

Yi-Min Mao

Bing-Yuan Wang

Jing-Min Zhao

Lun-Gen Lu

Bi-Hui Zhong

Zheng-Sheng Zou

You-Qing Xu

Yi-Nong Ye

Long-Gen Liu

Lian-Jie Lin

Hui-Ying Rao

Lai Wei

Affiliations

Soon will be listed here.

Abstract

Purpose: The Chronic Liver Disease Questionnaire (CLDQ)-Nonalcoholic Fatty Liver Disease (NAFLD) is a disease-specific instrument to assess the health-related quality of life (HRQL) of patients with NAFLD. In order to provide further evidence for the cross-cultural utility of this instrument in the Chinese population, we translated the CLDQ-NAFLD into Chinese and examined its reliability and validity.

Methods: Patients with NAFLD in 90 hospitals across China were enrolled in this multicenter cross-sectional survey. Eligible patients completed the Chinese version of CLDQ-NAFLD at enrollment to assess HRQL. Internal consistency of the questionnaire was assessed using Cronbach's alpha coefficient and split-half reliability. Convergent and discriminant validity were assessed using Spearman correlation coefficient. Factor analysis was used to test the construct validity.

Results: Between March and August 2019, 5181 patients with a mean age of 43.8 ± 13.3 years were enrolled. All domains exhibited good internal consistency, with Cronbach's alpha and split-half reliability greater than 0.70. The scaling success rate of all domains was 100% for convergent validity and 99.4% (179/180) for discriminant validity. The inter-scale correlations indicated a significant correlation between all CLDQ-NAFLD domains (r = 0.608 to 0.832, all p < 0.001). Factor analysis of 36 items extracted 6 factors, which explained 69.14% of the total variance.

Conclusion: The Chinese version of CLDQ-NAFLD is a reliable and valid instrument for assessing the HRQL of Chinese patients with NAFLD.

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