Role of Rho GTPases in Inflammatory Bowel Disease

Overview

Journal Cell Death Discov

Date 2023 Jan 23

PMID 36690621

Authors

Xiaoling Li

Mudan Zhang

Gaoshi Zhou

Zhuo Xie

Ying Wang

Jing Han

Li Li

Qirui Wu

Shenghong Zhang

Affiliations

Soon will be listed here.

Abstract

Rat sarcoma virus homolog (Rho) guanosine triphosphatases (GTPases) function as "molecular switch" in cellular signaling regulation processes and are associated with the pathogenesis of inflammatory bowel disease (IBD). This chronic intestinal tract inflammation primarily encompasses two diseases: Crohn's disease and ulcerative colitis. The pathogenesis of IBD is complex and considered to include four main factors and their interactions: genetics, intestinal microbiota, immune system, and environment. Recently, several novel pathogenic components have been identified. In addition, potential therapies for IBD targeting Rho GTPases have emerged and proven to be clinically effective. This review mainly focuses on Rho GTPases and their possible mechanisms in IBD pathogenesis. The therapeutic possibility of Rho GTPases is also discussed.

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