COVID-19 in Liver Transplant Patients: Impact and Considerations

Overview

Journal World J Transplant

Publisher Baishideng Publishing Group

Specialty General Surgery

Date 2023 Jan 23

PMID 36687560

Authors

Shrouq Khazaaleh

Mohammad Alomari

Sanskriti Sharma

Nikhil Kapila

Xaralambos Bobby Zervos

Adalberto Jose Gonzalez

Affiliations

Soon will be listed here.

Abstract

The coronavirus disease 2019 pandemic has significantly impacted liver tran splantation worldwide, leading to major effects on the transplant process, including the pretransplant, perioperative, and post-transplant periods. It is believed that patients with chronic liver disease, especially those with cirrhosis, have a higher risk of complications from coronavirus disease 2019 infection compared to the general population. However, evaluation of coronavirus disease 2019 effects on liver transplant patients has not uniformly demonstrated worse outcomes. Nonetheless, the pandemic created significant challenges and restrictions on transplant policies and organ allocation.

Citing Articles

Outcomes of COVID-19 in 24 hospitalized liver transplant recipients: an observational study.

Sadeghian A, Mansourian M, Ranjbar M, Kazemi S, Nojomi M, Zarghami S BMC Infect Dis. 2024; 24(1):1019.

PMID: 39304800 PMC: 11414169. DOI: 10.1186/s12879-024-09879-9.

Impact of COVID-19 on liver transplant recipients: A nationwide cohort study evaluating hospitalization, transplant rejection, and inpatient mortality.

Inayat F, Patel P, Ali H, Afzal A, Tahir H, Chaudhry A World J Transplant. 2024; 14(2):90866.

PMID: 38947960 PMC: 11212588. DOI: 10.5500/wjt.v14.i2.90866.

Outcomes of Liver Transplant Recipients Hospitalized With COVID-19: A Nationwide Analysis From the United States.

Ismail A, Goble S, Khalaf A, Abumuhfouz M, Al Sakaa Amini R, Jakhete N J Clin Exp Hepatol. 2024; 14(3):101350.

PMID: 38406613 PMC: 10882582. DOI: 10.1016/j.jceh.2024.101350.

Algorithmic Approach to Deranged Liver Functions After Transplantation.

Mishra S, Taneja S J Clin Exp Hepatol. 2024; 14(3):101317.

PMID: 38264576 PMC: 10801315. DOI: 10.1016/j.jceh.2023.101317.

Outcomes in Patients with Liver Dysfunction Post SARS-CoV-2 Infection: What Should We Measure?.

John N, Ibrahim B, Ebaid M, Saab S Hepat Med. 2023; 15:185-193.

PMID: 37850074 PMC: 10578169. DOI: 10.2147/HMER.S371507.

References

Guner R, Hasanoglu I, Aktas F . COVID-19: Prevention and control measures in community. Turk J Med Sci. 2020; 50(SI-1):571-577. PMC: 7195988. DOI: 10.3906/sag-2004-146. View

Gonzalez A, Kapila N, Thomas E, Pinna A, Tzakis A, Zervos X . Managing liver transplantation during the COVID-19 pandemic: A survey among transplant centers in the Southeast United States. World J Hepatol. 2022; 13(12):2161-2167. PMC: 8727207. DOI: 10.4254/wjh.v13.i12.2161. View

Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C . Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020; 8(4):420-422. PMC: 7164771. DOI: 10.1016/S2213-2600(20)30076-X. View

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J . Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020; 323(11):1061-1069. PMC: 7042881. DOI: 10.1001/jama.2020.1585. View

Faruqui S, Okoli F, Olsen S, Feldman D, Kalia H, Park J . Cholangiopathy After Severe COVID-19: Clinical Features and Prognostic Implications. Am J Gastroenterol. 2021; 116(7):1414-1425. DOI: 10.14309/ajg.0000000000001264. View

Andersen M, Ostergaard L, Phelps M, Butt J, Kober L, Gislason G . Risk of coronavirus disease 2019 (Covid-19) contraction and severe infection in home- or healthcare professionals. J Infect. 2021; 83(2):e12-e14. PMC: 8245749. DOI: 10.1016/j.jinf.2021.06.012. View

Craig-Schapiro R, Salinas T, Lubetzky M, Abel B, Sultan S, Lee J . COVID-19 outcomes in patients waitlisted for kidney transplantation and kidney transplant recipients. Am J Transplant. 2020; 21(4):1576-1585. PMC: 7675359. DOI: 10.1111/ajt.16351. View

Webb G, Marjot T, Cook J, Aloman C, Armstrong M, Brenner E . Outcomes following SARS-CoV-2 infection in liver transplant recipients: an international registry study. Lancet Gastroenterol Hepatol. 2020; 5(11):1008-1016. PMC: 7455160. DOI: 10.1016/S2468-1253(20)30271-5. View

Fischer 2nd W, Eron Jr J, Holman W, Cohen M, Fang L, Szewczyk L . A phase 2a clinical trial of molnupiravir in patients with COVID-19 shows accelerated SARS-CoV-2 RNA clearance and elimination of infectious virus. Sci Transl Med. 2021; 14(628):eabl7430. PMC: 10763622. DOI: 10.1126/scitranslmed.abl7430. View

10.

Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y . Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020; 395(10223):507-513. PMC: 7135076. DOI: 10.1016/S0140-6736(20)30211-7. View

11.

Ahearn A, Maw T, Mehta R, Emamaullee J, Kim J, Blodget E . A Programmatic Response, Including Bamlanivimab or Casirivimab-imdevimab Administration, Reduces Hospitalization and Death in COVID-19 Positive Abdominal Transplant Recipients. Transplantation. 2021; 106(2):e153-e157. DOI: 10.1097/TP.0000000000003953. View

12.

Nagarajan R, Krishnamoorthy Y, Rajaa S, Hariharan V . COVID-19 Severity and Mortality Among Chronic Liver Disease Patients: A Systematic Review and Meta-Analysis. Prev Chronic Dis. 2022; 19:E53. PMC: 9480842. DOI: 10.5888/pcd19.210228. View

13.

Yao X, Li T, He Z, Ping Y, Liu H, Yu S . [A pathological report of three COVID-19 cases by minimal invasive autopsies]. Zhonghua Bing Li Xue Za Zhi. 2020; 49(5):411-417. DOI: 10.3760/cma.j.cn112151-20200312-00193. View

14.

Colmenero J, Rodriguez-Peralvarez M, Salcedo M, Arias-Milla A, Munoz-Serrano A, Graus J . Epidemiological pattern, incidence, and outcomes of COVID-19 in liver transplant patients. J Hepatol. 2020; 74(1):148-155. PMC: 7395653. DOI: 10.1016/j.jhep.2020.07.040. View

15.

Ge J, Pletcher M, Lai J . Outcomes of SARS-CoV-2 Infection in Patients With Chronic Liver Disease and Cirrhosis: A National COVID Cohort Collaborative Study. Gastroenterology. 2021; 161(5):1487-1501.e5. PMC: 8286237. DOI: 10.1053/j.gastro.2021.07.010. View

16.

Ibrahim B, Dawson R, Chandler J, Goldberg A, Hartell D, Hornby L . The COVID-19 pandemic and organ donation and transplantation: ethical issues. BMC Med Ethics. 2021; 22(1):142. PMC: 8528937. DOI: 10.1186/s12910-021-00711-6. View

17.

Trotter J, Cardenas A . Liver transplantation around the world. Liver Transpl. 2016; 22(8):1059-61. DOI: 10.1002/lt.24508. View

18.

Ngamprasertchai T, Kajeekul R, Sivakorn C, Ruenroegnboon N, Luvira V, Siripoon T . Efficacy and Safety of Immunomodulators in Patients with COVID-19: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials. Infect Dis Ther. 2021; 11(1):231-248. PMC: 8579415. DOI: 10.1007/s40121-021-00545-0. View

19.

Ai J, Wang J, Liu D, Xiang H, Guo Y, Lv J . Safety and Immunogenicity of SARS-CoV-2 Vaccines in Patients With Chronic Liver Diseases (CHESS-NMCID 2101): A Multicenter Study. Clin Gastroenterol Hepatol. 2021; 20(7):1516-1524.e2. PMC: 8686447. DOI: 10.1016/j.cgh.2021.12.022. View

20.

Becchetti C, Gschwend S, Dufour J, Banz V . COVID-19 in Liver Transplant Recipients: A Systematic Review. J Clin Med. 2021; 10(17). PMC: 8432463. DOI: 10.3390/jcm10174015. View