Peptidoglycan-Directed Chemical Ligation for Selective Inhibition on Gram-Positive Bacteria

Overview

Journal ACS Omega

Publisher American Chemical Society

Specialty Chemistry

Date 2023 Jan 23

PMID 36687063

Authors

Feng Jiang

Chengteng Cai

Lei Gao

Xinhui Su

Shoufa Han

Affiliations

Soon will be listed here.

Abstract

Microbicides with distinct antibacterial mechanisms show potential to combat multi-drug resistance bacteria. We herein report peptidoglycan-directed chemical ligation (PGCL) between alkyne-bearing vancomycin and an azide-tagged cationic polymer. The former binds peptidoglycan and inhibits peptidoglycan crosslinking, while the latter interferes the integrity of the bacterial membrane. PGCL results in enhanced bactericidal activity against Gram-positive () over Gram-negative (). These data indicate the potential of PGCL to selectively and synergistically inhibit Gram-positive pathogens via dual modality antibacterial mechanisms of peptidoglycan-inhibiting antibiotics and bacterial membrane-disrupting polycations.

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