Is Periodontitis a Risk Factor for Lung Cancer? A Meta-Analysis and Detailed Review of Mechanisms of Association

Overview

Journal Contemp Clin Dent

Specialty Dentistry

Date 2023 Jan 23

PMID 36686995

Authors

Pooja Kesharani

Payalben Kansara

Tikal Kansara

Arjun Kini

Raksha Bhat

Preethesh Shetty

Bapanaiah Penugonda

Affiliations

Soon will be listed here.

Abstract

Background: Numerous studies have explored the correlation of periodontal disease (PD) with the risk of lung cancers, but the findings were inconsistent. Therefore, we did a meta-analysis to ascertain the correlation of PD with the risk of incident lung cancer.

Methods: The authors searched relevant studies in databases (PubMed, Web of Science, Scopus, Embase, and MEDLINE) till November 2020. We registered the study at the International database of Prospectively Registered Systemic Reviews under the CRD42020198119. The summary relative risk (RR) along with a 95% confidence interval (CI) was calculated using fixed-effects models.

Results: Twelve studies were included in the qualitative synthesis. The pooled analysis revealed that PD was significantly associated with an increased risk of lung cancer (RR 1.71; 95%CI 1.61-1.81; < 0.01). Subgroup analysis was performed based on gender distribution, geographic location, and type of studies.

Conclusion: From this current evidence, PD is a potential risk factor for the development of lung cancer. The risk for incidence of lung cancer is surged twice in the patients with PD, even though age and smoking are controlled in the studies.

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