Mechanism of Ferroptosis in Traditional Chinese Medicine for Clinical Treatment: A Review

Overview

Journal Front Pharmacol

Date 2023 Jan 23

PMID 36686700

Authors

Jiajiao Liu

Guanyin Jiang

Pengfei He

Xing Du

Zhenming Hu

Fuxiang Li

Affiliations

Soon will be listed here.

Abstract

Ferroptosis is an iron-dependent regulation of cell death driven by lipid peroxidation, which is intracellularly dependent on iron and independent of other metals, and morphologically, biochemically, and genetically distinct from apoptosis, necrosis, and autophagy. Ferroptosis is closely related to physiological and pathological processes, such as development, aging, and immunity, and it plays an important role in a variety of diseases. In many departments, traditional Chinese medicine plays an increasingly important role in their clinical treatment. In recent years, an increasing number of studies have been conducted on the mechanism of ferroptosis in traditional Chinese medicine. However, the role of ferroptosis in the clinical treatment of traditional Chinese medicine requires further exploration. This article mainly introduces the application of ferroptosis in studies of the mechanism of traditional Chinese medicine to help clinicians understand the current status of traditional Chinese medicine therapy for the treatment of ferroptosis-related diseases.

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References

Stockwell B, Jiang X . A Physiological Function for Ferroptosis in Tumor Suppression by the Immune System. Cell Metab. 2019; 30(1):14-15. PMC: 6944065. DOI: 10.1016/j.cmet.2019.06.012. View

Li F, Long H, Zhou Z, Luo H, Xu S, Gao L . System X /GSH/GPX4 : An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy. Front Pharmacol. 2022; 13:910292. PMC: 9465090. DOI: 10.3389/fphar.2022.910292. View

Hambright W, Fonseca R, Chen L, Na R, Ran Q . Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration. Redox Biol. 2017; 12:8-17. PMC: 5312549. DOI: 10.1016/j.redox.2017.01.021. View

Li J, Lu K, Sun F, Tan S, Zhang X, Sheng W . Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2/HO-1 pathway. J Transl Med. 2021; 19(1):96. PMC: 7927246. DOI: 10.1186/s12967-021-02745-1. View

Oh S, Ikeda M, Ide T, Hur K, Lee M . Mitochondrial event as an ultimate step in ferroptosis. Cell Death Discov. 2022; 8(1):414. PMC: 9547870. DOI: 10.1038/s41420-022-01199-8. View

Huang X, Wang J, Lin W, Zhang N, Du J, Long Z . Kanglaite injection plus platinum-based chemotherapy for stage III/IV non-small cell lung cancer: A meta-analysis of 27 RCTs. Phytomedicine. 2020; 67:153154. DOI: 10.1016/j.phymed.2019.153154. View

Sun L, Linghu D, Hung M . Ferroptosis: a promising target for cancer immunotherapy. Am J Cancer Res. 2022; 11(12):5856-5863. PMC: 8727800. View

Lv Y, Feng Q, Zhang Z, Zheng P, Zhu D, Lin Q . Low ferroptosis score predicts chemotherapy responsiveness and immune-activation in colorectal cancer. Cancer Med. 2022; 12(2):2033-2045. PMC: 9883409. DOI: 10.1002/cam4.4956. View

Wu Z, Khodade V, Chauvin J, Rodriguez D, Toscano J, Pratt D . Hydropersulfides Inhibit Lipid Peroxidation and Protect Cells from Ferroptosis. J Am Chem Soc. 2022; 144(34):15825-15837. DOI: 10.1021/jacs.2c06804. View

10.

Fang L, Zhang Y, Wang Q, Zang Y, Li Z, Duan Z . A polysaccharide from Huaier ameliorates cisplatin nephrotoxicity by decreasing oxidative stress and apoptosis via PI3K/AKT signaling. Int J Biol Macromol. 2019; 139:932-943. DOI: 10.1016/j.ijbiomac.2019.07.219. View

11.

Shao J, Bai Z, Zhang L, Zhang F . Ferrostatin-1 alleviates tissue and cell damage in diabetic retinopathy by improving the antioxidant capacity of the Xc-GPX4 system. Cell Death Discov. 2022; 8(1):426. PMC: 9596714. DOI: 10.1038/s41420-022-01141-y. View

12.

Yang C, Huang S, Cao F, Zheng Y . Role of ferroptosis-related genes in prognostic prediction and tumor immune microenvironment in colorectal carcinoma. PeerJ. 2021; 9:e11745. PMC: 8286063. DOI: 10.7717/peerj.11745. View

13.

Wang Z, Li M, Liu Y, Qiao Z, Bai T, Yang L . Dihydroartemisinin triggers ferroptosis in primary liver cancer cells by promoting and unfolded protein response‑induced upregulation of CHAC1 expression. Oncol Rep. 2021; 46(5). PMC: 8485000. DOI: 10.3892/or.2021.8191. View

14.

Huang Y, Yang Y, Xu Y, Ma Q, Guo F, Zhao Y . Nrf2/HO-1 Axis Regulates the Angiogenesis of Gastric Cancer via Targeting VEGF. Cancer Manag Res. 2021; 13:3155-3169. PMC: 8055645. DOI: 10.2147/CMAR.S292461. View

15.

Wang N, Yu Y, Wang R, Chen Y, Tang J . mRNA-Modified FUS/NRF2 Signalling Inhibits Ferroptosis and Promotes Prostate Cancer Growth. Comput Math Methods Med. 2022; 2022:8509626. PMC: 9410928. DOI: 10.1155/2022/8509626. View

16.

Lan B, Ge J, Cheng S, Zheng X, Liao J, He C . Extract of Naotaifang, a compound Chinese herbal medicine, protects neuron ferroptosis induced by acute cerebral ischemia in rats. J Integr Med. 2020; 18(4):344-350. DOI: 10.1016/j.joim.2020.01.008. View

17.

Hu J, Gu W, Ma N, Fan X, Ci X . Leonurine alleviates ferroptosis in cisplatin-induced acute kidney injury by activating the Nrf2 signalling pathway. Br J Pharmacol. 2022; 179(15):3991-4009. DOI: 10.1111/bph.15834. View

18.

Lin Y, Xu W, Hou Y, Wang S, Zhang H, Ran M . The multifaceted role of ferroptosis in kidney diseases. Chem Biol Interact. 2022; 365:110107. DOI: 10.1016/j.cbi.2022.110107. View

19.

Chintharlapalli S, Papineni S, Lei P, Pathi S, Safe S . Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors. BMC Cancer. 2011; 11:371. PMC: 3170653. DOI: 10.1186/1471-2407-11-371. View

20.

Li Y, Zhang Y, Qiu Q, Wang L, Mao H, Hu J . Energy-Stress-Mediated AMPK Activation Promotes GPX4-Dependent Ferroptosis through the JAK2/STAT3/P53 Axis in Renal Cancer. Oxid Med Cell Longev. 2022; 2022:2353115. PMC: 9554664. DOI: 10.1155/2022/2353115. View