Potential Therapeutic Effect of NK1R Antagonist in Diabetic Non-healing Wound and Depression

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2023 Jan 23

PMID 36686487

Authors

Mingyu Li

Hao Ma

Shunuo Zhang

Yuan Peng

Liang Ding

Yixin Zhang

Peiru Min

Affiliations

Soon will be listed here.

Abstract

Diabetes is a global disease with huge impacts on patients due to its complications, among which non-healing wounds and depression are common and challenging. The neurokinin 1 receptor (NK1R) inhibitor, aprepitant has been broadly applied for an antidepressant effect in depressive patients. Recent literature has indicated a therapeutic effect of downregulation in NK1R to diabetes-related fracture, cardiomyopathy, gastroparesis, and ocular surface disorders. In this study, differential expression genes in diabetes and depression were analyzed based on several RNA sequencing datasets from the GEO database to confirm NK1R in the overlapping set. Interaction network and gene set enrichment analysis were subsequently conducted. As a result, NK1R-related genes took part in angiogenesis, epithelial-mesenchymal transition (EMT), collagen deposition, and inflammation in diabetes and depression. , the downregulation of NK1R was proved to promote vascular proliferation and enhance diabetic wound healing, which provides a potential therapeutic target for the management of diabetic non-healing wounds and depression.

Citing Articles

Depression clinical trials worldwide: a systematic analysis of the ICTRP and comparison with ClinicalTrials.gov.

Namiot E, Smirnovova D, Sokolov A, Chubarev V, Tarasov V, Schioth H Transl Psychiatry. 2024; 14(1):315.

PMID: 39085220 PMC: 11291508. DOI: 10.1038/s41398-024-03031-6.

Improving depression-like behaviors caused by diabetes is likely to offer a new perspective for the treatment of non-healing chronic wounds.

Dong Z, Wu J, Cao H, Lu J Front Behav Neurosci. 2024; 18:1348898.

PMID: 38440257 PMC: 10910048. DOI: 10.3389/fnbeh.2024.1348898.

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