Habitual Khat Chewing and Oral Melanoacanthoma: A Case Report

Overview

Journal World J Clin Cases

Publisher Baishideng Publishing Group

Specialty General Medicine

Date 2023 Jan 23

PMID 36686340

Authors

Hamad AlBagieh

Ashwag Aloyouny

Rana Alshagroud

Abdulaziz Alwakeel

Shahad Alkait

Fatimah Almufarji

Ghadeer Almutairi

Rana Alkhalaf

Affiliations

Soon will be listed here.

Abstract

Background: Habitual khat () chewing has been proven to cause numerous oral tissue changes. However, oral melanoacanthoma triggered by chronic khat chewing is rare. Oral melanoacanthoma is an uncommon, sudden, asymptomatic, benign pigmentation of the oral cavity. Under the microscope, the epithelial layer of the oral mucosa showed dendritic melanocyte proliferation and acanthosis. The study aimed to highlight chronic khat chewing as a trigger for oral melanoacanthoma.

Case Summary: In the current study, we report a case of a 26-year-old male patient with a rare presentation of oral melanoacanthoma triggered by regular khat chewing. Many intrinsic and extrinsic factors can cause oral pigmentation. Chewing khat is an extrinsic factor that can cause several diseases, including oral pigmentation. In this case, the definitive diagnosis was oral melanoacanthoma. This diagnosis was made based on the patient's history, clinical lesion presentation, and microscopic biopsy results.

Conclusion: Habitual khat () chewing causes many oral tissue changes including oral melanoacanthoma. The study aimed to highlight chronic khat chewing as a trigger for oral melanoacanthoma.

Citing Articles

[Rapid extraction and detection of five alkaloids in dried khat by solvent extraction-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry].

Shi H, Xu B, Xu C, Zhou X, Xu H Se Pu. 2023; 41(9):771-780.

PMID: 37712541 PMC: 10507533. DOI: 10.3724/SP.J.1123.2023.03009.

References

Al-Sharabi A, Shuga-Aldin H, Ghandour I, Al-Hebshi N . Qat chewing as an independent risk factor for periodontitis: a cross-sectional study. Int J Dent. 2013; 2013:317640. PMC: 3594978. DOI: 10.1155/2013/317640. View

Brooks J, Sindler A, Scheper M . Oral melanoacanthoma in an adolescent. Pediatr Dermatol. 2010; 27(4):384-7. DOI: 10.1111/j.1525-1470.2010.01177.x. View

Fornatora M, Reich R, Haber S, Solomon F, Freedman P . Oral melanoacanthoma: a report of 10 cases, review of the literature, and immunohistochemical analysis for HMB-45 reactivity. Am J Dermatopathol. 2003; 25(1):12-5. DOI: 10.1097/00000372-200302000-00003. View

Agha R, Borrelli M, Farwana R, Koshy K, Fowler A, Orgill D . The SCARE 2018 statement: Updating consensus Surgical CAse REport (SCARE) guidelines. Int J Surg. 2018; 60:132-136. DOI: 10.1016/j.ijsu.2018.10.028. View

Galindo-Moreno P, Padial-Molina M, Gomez-Morales M, Aneiros-Fernandez J, Mesa F, OValle F . Multifocal oral melanoacanthoma and melanotic macula in a patient after dental implant surgery. J Am Dent Assoc. 2011; 142(7):817-24. DOI: 10.14219/jada.archive.2011.0270. View

Tomich C, Zunt S . Melanoacanthosis (melanoacanthoma) of the oral mucosa. J Dermatol Surg Oncol. 1990; 16(3):231-6. DOI: 10.1111/j.1524-4725.1990.tb03958.x. View

Al-Kholani A . Influence of Khat Chewing on Periodontal Tissues and Oral Hygiene Status among Yemenis. Dent Res J (Isfahan). 2011; 7(1):1-6. PMC: 3065335. View

Ageely H . Health and socio-economic hazards associated with khat consumption. J Family Community Med. 2012; 15(1):3-11. PMC: 3377054. View

Cantudo-Sanagustin E, Gutierrez-Corrales A, Vigo-Martinez M, Serrera-Figallo M, Torres-Lagares D, Gutierrez-Perez J . Pathogenesis and clinicohistopathological caractheristics of melanoacanthoma: A systematic review. J Clin Exp Dent. 2016; 8(3):e327-36. PMC: 4930645. DOI: 10.4317/jced.52860. View

10.

Hijazi M, Jentsch H, Al-Sanabani J, Tawfik M, Remmerbach T . Clinical and cytological study of the oral mucosa of smoking and non-smoking qat chewers in Yemen. Clin Oral Investig. 2015; 20(4):771-9. DOI: 10.1007/s00784-015-1569-2. View

11.

Feller L, Masilana A, Khammissa R, Altini M, Jadwat Y, Lemmer J . Melanin: the biophysiology of oral melanocytes and physiological oral pigmentation. Head Face Med. 2014; 10:8. PMC: 3994327. DOI: 10.1186/1746-160X-10-8. View

12.

Al-Maweri S, A Alaizari N, Al-Sufyani G . Oral mucosal lesions and their association with tobacco use and qat chewing among Yemeni dental patients. J Clin Exp Dent. 2015; 6(5):e460-6. PMC: 4312669. DOI: 10.4317/jced.51706. View

13.

Al-Hebshi N, Skaug N . Khat (Catha edulis)-an updated review. Addict Biol. 2005; 10(4):299-307. DOI: 10.1080/13556210500353020. View

14.

Awadalla N, Suwaydi H . Prevalence, determinants and impacts of khat chewing among professional drivers in Southwestern Saudi Arabia. East Mediterr Health J. 2017; 23(3):189-197. DOI: 10.26719/2017.23.3.189. View

15.

Al-Maweri S, Warnakulasuriya S, Samran A . Khat (Catha edulis) and its oral health effects: An updated review. J Investig Clin Dent. 2017; 9(1). DOI: 10.1111/jicd.12288. View

16.

Gondak R, da Silva-Jorge R, Jorge J, Lopes M, Vargas P . Oral pigmented lesions: Clinicopathologic features and review of the literature. Med Oral Patol Oral Cir Bucal. 2012; 17(6):e919-24. PMC: 3505710. DOI: 10.4317/medoral.17679. View

17.

Carlos-Bregni R, Contreras E, Netto A, Mosqueda-Taylor A, Vargas P, Jorge J . Oral melanoacanthoma and oral melanotic macule: a report of 8 cases, review of the literature, and immunohistochemical analysis. Med Oral Patol Oral Cir Bucal. 2007; 12(5):E374-9. View

18.

Tapia J, Quezada D, Gaitan L, Hernandez J, Paez C, Aguirre A . Gingival melanoacanthoma: case report and discussion of its clinical relevance. Quintessence Int. 2011; 42(3):253-8. View

19.

Kassim S, Jawad M, Croucher R, Akl E . The Epidemiology of Tobacco Use among Khat Users: A Systematic Review. Biomed Res Int. 2015; 2015:313692. PMC: 4529904. DOI: 10.1155/2015/313692. View