Molecular Mechanisms of Long Noncoding RNAs Associated with Cervical Cancer Radiosensitivity

Overview

Journal Front Genet

Date 2023 Jan 23

PMID 36685972

Authors

Shuying Wu

He Zhu

Yishi Wu

Cong Wang

Xuefeng Duan

Tianmin Xu

Affiliations

Soon will be listed here.

Abstract

Despite advances in cervical cancer screening and human papilloma virus (HPV) vaccines, cervical cancer remains a global health burden. The standard treatment of cervical cancer includes surgery, radiation therapy, and chemotherapy. Radiotherapy (RT) is the primary treatment for advanced-stage disease. However, due to radioresistance, most patients in the advanced stage have an adverse outcome. Recent studies have shown that long noncoding RNAs (lncRNAs) participate in the regulation of cancer radiosensitivity by regulating DNA damage repair, apoptosis, cancer stem cells (CSCs), and epithelial-mesenchymal transition (EMT). In this review, we summarize the molecular mechanisms of long noncoding RNAs in cervical cancer and radiosensitivity, hoping to provide a theoretical basis and a new molecular target for the cervical cancer RT in the clinic.

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