Interleukin 11 Confers Resistance to Dextran Sulfate Sodium-induced Colitis in Mice

Overview

Journal iScience

Publisher Cell Press

Date 2023 Jan 23

PMID 36685040

Authors

Takashi Nishina

Yutaka Deguchi

Mika Kawauchi

Chen Xiyu

Soh Yamazaki

Tetuo Mikami

Hiroyasu Nakano

Affiliations

Soon will be listed here.

Abstract

Intestinal homeostasis is tightly regulated by epithelial cells, leukocytes, and stromal cells, and its dysregulation is associated with inflammatory bowel diseases. Interleukin (IL)-11, a member of the IL-6 family of cytokines, is produced by inflammatory fibroblasts during acute colitis. However, the role of IL-11 in the development of colitis is still unclear. Herein, we showed that IL-11 ameliorated DSS-induced acute colitis in mouse models. We found that deletion of or rendered mice highly susceptible to DSS-induced colitis compared to the respective control mice. The number of apoptotic epithelial cells was increased in DSS-treated or deficient mice. Moreover, we showed that IL-11 production was regulated by reactive oxygen species (ROS) produced by -positive myeloid cells. These findings indicate that fibroblast-produced IL-11 plays an important role in protecting the mucosal epithelium in acute colitis. Myeloid cell-derived ROS contribute to the attenuation of colitis through the production of IL-11.

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