Conditioned Medium from Human Cord Blood Mesenchymal Stem Cells Attenuates Age-related Immune Dysfunctions

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2023 Jan 23

PMID 36684433

Authors

Bo Sun

Xianhui Meng

Yumin Li

Yanlong Li

Rui Liu

Zhongdang Xiao

Affiliations

Soon will be listed here.

Abstract

Aging is accompanied with progressive deterioration of immune responses and tissue's function. Using 12-month-old mice as model, we showed that conditioned medium of human cord blood mesenchymal stem cells (CBMSC-CM) significantly reduced the population percentage of CD3CD335 NK and CD4CD25 regulatory T-cells in peripheral blood. The CBMSC-CM administration also increased naïve T-cells number and restored the ratio of naïve to memory T-cells in CD4 T-cells population. These results indicated that CBMSC-CM improved the immune response efficiency of aged mice. Moreover, we also found CBMSC-CM treatment significantly reduced the number of senescenT-cells in kidney tissues. Finally, we demonstrated that CBMSC-CM remarkably attenuated hydrogen peroxide triggered T-cell response and ameliorated oxidative stress induced cellular senescence. All of these data suggest a prominent anti-aging effect of secretome of CBMSCs.

Citing Articles

A Comprehensive Review of Stem Cell Conditioned Media Role for Anti-Aging on Skin.

Alquraisy A, Wilar G, Mohammed A, El-Rayyes A, Suhandi C, Wathoni N Stem Cells Cloning. 2024; 17:5-19.

PMID: 39310304 PMC: 11416772. DOI: 10.2147/SCCAA.S480437.

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