The Role of Laparoscopic Surgery in the Surgical Management of Recurrent Liver Malignancies: A systematic Review and Meta-analysis

Overview

Journal Front Surg

Specialty General Surgery

Date 2023 Jan 23

PMID 36684258

Authors

Tian-Run Lv

Hai-Jie Hu

Wen-Jie Ma

Ya-Fei Hu

Yu-Shi Dai

Fu-Yu Li

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate the efficiency of laparoscopic surgery in treating recurrent liver tumors vs. conventional open surgery.

Methods: Database searching was conducted in PubMed, the Cochrane Library and EMBASE. Rev Man 5.3 software and Stata 13.0 software were applied in statistical analyses.

Results: A total of fourteen studies were finally included with 1,284 patients receiving LRH and 2,254 with ORH. LRH was associated with less intraoperative hemorrhage, a higher R0 resection rate, a lower incidence of Pringle Maneuver, a lower incidence of postoperative morbidities, a better overall survival and an enhanced postoperative recovery vs. ORH. Patients receiving LRH shared similar operative time, tumor number and disease-free survival as those with ORH. However, tumor size was relatively larger in patients receiving ORH and major hepatectomy, anatomic hepatectomy were rarely performed in patients with LRH. Additional analyses between LRH and laparoscopic primary hepatectomy revealed less intraoperative blood loss in patients with LRH.

Conclusion: LRH is safe and feasible with more favorable peri-operative outcomes and faster postoperative recovery. However, it is only applicable for some highly-selected cases not requiring complex surgical procedures. Future larger well-designed studies are expected for further validation.

Citing Articles

Advances in minimally invasive liver surgery.

Dincer H, Dogrul A North Clin Istanb. 2024; 11(6):586-592.

PMID: 39650315 PMC: 11622747. DOI: 10.14744/nci.2024.42744.

References

Lv T, Liu F, Hu H, Regmi P, Ma W, Yang Q . The role of extra-hepatic bile duct resection in the surgical management of gallbladder carcinoma. A first meta-analysis. Eur J Surg Oncol. 2021; 48(3):482-491. DOI: 10.1016/j.ejso.2021.11.131. View

Kanazawa A, Tsukamoto T, Shimizu S, Kodai S, Yamamoto S, Yamazoe S . Laparoscopic liver resection for treating recurrent hepatocellular carcinoma. J Hepatobiliary Pancreat Sci. 2013; 20(5):512-7. DOI: 10.1007/s00534-012-0592-9. View

Witowski J, Rubinkiewicz M, Mizera M, Wysocki M, Gajewska N, Sitkowski M . Meta-analysis of short- and long-term outcomes after pure laparoscopic versus open liver surgery in hepatocellular carcinoma patients. Surg Endosc. 2018; 33(5):1491-1507. PMC: 6484823. DOI: 10.1007/s00464-018-6431-6. View

Nomi T, Fuks D, Ogiso S, Nakajima Y, Louvet C, Gayet B . Second and Third Laparoscopic Liver Resection for Patients With Recurrent Colorectal Liver Metastases. Ann Surg. 2015; 263(5):e68-72. DOI: 10.1097/SLA.0000000000001528. View

Poon R, Fan S, Lo C, Ng I, Liu C, Lam C . Improving survival results after resection of hepatocellular carcinoma: a prospective study of 377 patients over 10 years. Ann Surg. 2001; 234(1):63-70. PMC: 1421949. DOI: 10.1097/00000658-200107000-00010. View

Abu Hilal M, Aldrighetti L, Dagher I, Edwin B, Troisi R, Alikhanov R . The Southampton Consensus Guidelines for Laparoscopic Liver Surgery: From Indication to Implementation. Ann Surg. 2017; 268(1):11-18. DOI: 10.1097/SLA.0000000000002524. View

Liu K, Chen Y, Wu X, Huang Z, Lin Z, Jiang J . Laparoscopic liver re-resection is feasible for patients with posthepatectomy hepatocellular carcinoma recurrence: a propensity score matching study. Surg Endosc. 2017; 31(11):4790-4798. DOI: 10.1007/s00464-017-5556-3. View

Noda T, Eguchi H, Wada H, Iwagami Y, Yamada D, Asaoka T . Short-term surgical outcomes of minimally invasive repeat hepatectomy for recurrent liver cancer. Surg Endosc. 2017; 32(1):46-52. DOI: 10.1007/s00464-017-5632-8. View

Clavien P, Selzner M, Rudiger H, Graf R, Kadry Z, Rousson V . A prospective randomized study in 100 consecutive patients undergoing major liver resection with versus without ischemic preconditioning. Ann Surg. 2003; 238(6):843-50. PMC: 1356166. DOI: 10.1097/01.sla.0000098620.27623.7d. View

10.

Shin J, Kim H, Lee W, Yun S, Cho Y, Huh J . Comparative study of laparoscopic versus open technique for simultaneous resection of colorectal cancer and liver metastases with propensity score analysis. Surg Endosc. 2019; 34(11):4772-4780. DOI: 10.1007/s00464-019-07253-4. View

11.

Clarysse M, Van Aelst P, Vanuytsel T, Monbaliu D, Ceulemans L, Mertens A . Laparoscopic Sleeve Gastrectomy for Obesity After Combined Liver-intestinal Transplantation: A Case Report. Transplantation. 2022; 107(1):e37-e38. DOI: 10.1097/TP.0000000000004375. View

12.

Zhang J, Zhou Z, Huang Z, Yang K, Chen J, Chen J . Prospective, single-center cohort study analyzing the efficacy of complete laparoscopic resection on recurrent hepatocellular carcinoma. Chin J Cancer. 2016; 35:25. PMC: 4784396. DOI: 10.1186/s40880-016-0088-0. View

13.

Nakajima Y, Ko S, Kanamura T, Nagao M, Kanehiro H, Hisanaga M . Repeat liver resection for hepatocellular carcinoma. J Am Coll Surg. 2001; 192(3):339-44. DOI: 10.1016/s1072-7515(00)00789-4. View

14.

Liberati A, Altman D, Tetzlaff J, Mulrow C, Gotzsche P, Ioannidis J . The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med. 2009; 6(7):e1000100. PMC: 2707010. DOI: 10.1371/journal.pmed.1000100. View

15.

Chan A, Poon R, Chok K, Cheung T, Chan S, Lo C . Feasibility of laparoscopic re-resection for patients with recurrent hepatocellular carcinoma. World J Surg. 2013; 38(5):1141-6. DOI: 10.1007/s00268-013-2380-3. View

16.

Onoe T, Yamaguchi M, Irei T, Ishiyama K, Sudo T, Hadano N . Feasibility and efficacy of repeat laparoscopic liver resection for recurrent hepatocellular carcinoma. Surg Endosc. 2019; 34(10):4574-4581. DOI: 10.1007/s00464-019-07246-3. View

17.

Minagawa M, Makuuchi M, Takayama T, Kokudo N . Selection criteria for repeat hepatectomy in patients with recurrent hepatocellular carcinoma. Ann Surg. 2003; 238(5):703-10. PMC: 1356149. DOI: 10.1097/01.sla.0000094549.11754.e6. View

18.

Shafaee Z, Kazaryan A, Marvin M, Cannon R, Buell J, Edwin B . Is laparoscopic repeat hepatectomy feasible? A tri-institutional analysis. J Am Coll Surg. 2011; 212(2):171-9. DOI: 10.1016/j.jamcollsurg.2010.10.012. View

19.

Gon H, Kido M, Tanaka M, Kuramitsu K, Komatsu S, Awazu M . Laparoscopic repeat hepatectomy is a more favorable treatment than open repeat hepatectomy for contralateral recurrent hepatocellular carcinoma cases. Surg Endosc. 2020; 35(6):2896-2906. DOI: 10.1007/s00464-020-07728-9. View

20.

Van der Poel M, Barkhatov L, Fuks D, Berardi G, Cipriani F, Aljaiuossi A . Multicentre propensity score-matched study of laparoscopic versus open repeat liver resection for colorectal liver metastases. Br J Surg. 2019; 106(6):783-789. DOI: 10.1002/bjs.11096. View