Correlations Between Cortical Gyrification and Schizophrenia Symptoms with and Without Comorbid Hostility Symptoms

Overview

Journal Front Psychiatry

Specialty Psychiatry

Date 2023 Jan 23

PMID 36684000

Authors

Stefano Ferracuti

Antonio Del Casale

Andrea Romano

Ida Gualtieri

Martina Lucignani

Antonio Napolitano

Martina Nicole Modesti

Andrea Buscajoni

Teodolinda Zoppi

Georgios D Kotzalidis

Lorenza Manelfi

Eleonora De Pisa

Paolo Girardi

Gabriele Mandarelli

Giovanna Parmigiani

Maria Camilla Rossi-Espagnet

Maurizio Pompili

Alessandro Bozzao

Affiliations

Soon will be listed here.

Abstract

Introduction: Interest in identifying the clinical implications of the neuropathophysiological background of schizophrenia is rising, including changes in cortical gyrification that may be due to neurodevelopmental abnormalities. Inpatients with schizophrenia can show abnormal gyrification of cortical regions correlated with the symptom severity.

Methods: Our study included 36 patients that suffered an acute episode of schizophrenia and have undergone structural magnetic resonance imaging (MRI) to calculate the local gyrification index (LGI).

Results: In the whole sample, the severity of symptoms significantly correlated with higher LGI in different cortical areas, including bilateral frontal, cingulate, parietal, temporal cortices, and right occipital cortex. Among these areas, patients with low hostility symptoms (LHS) compared to patients with high hostility symptoms (HHS) showed significantly lower LGI related to the severity of symptoms in bilateral frontal and temporal lobes.

Discussion: The severity of psychopathology correlated with higher LGI in large portions of the cerebral cortex, possibly expressing abnormal neural development in schizophrenia. These findings could pave the way for further studies and future tailored diagnostic and therapeutic strategies.

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