Liver Injury in COVID-19: Holds Ferritinophagy-mediated Ferroptosis Accountable

Overview

Journal World J Clin Cases

Publisher Baishideng Publishing Group

Specialty General Medicine

Date 2023 Jan 23

PMID 36683648

Authors

Feng-Ju Jia

Jing Han

Affiliations

Soon will be listed here.

Abstract

Even in patients without a history of liver disease, liver injury caused by coronavirus disease 2019 (COVID-19) is gradually becoming more common. However, the precise pathophysiological mechanisms behind COVID-19's liver pathogenicity are still not fully understood. We hypothesize that inflammation may become worse by cytokine storms caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Elevated ferritin levels can initiate ferritinophagy mediated by nuclear receptor coactivator 4 (NCOA4), which leads to iron elevation, and ferroptosis. In COVID-19 patients, ferroptosis can be restricted to reduce disease severity and liver damage by targeting NCOA4-mediated ferritinophagy. To confirm the role of ferritinophagy-mediated ferroptosis in SARS-CoV-2 infection, further research is required.

Citing Articles

Jia F, Han J Cell Death Discov. 2024; 10(1):146.

PMID: 38503730 PMC: 10951317. DOI: 10.1038/s41420-024-01915-6.

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