Fabrication of a Dual-Drug-Loaded Smart Niosome-g-Chitosan Polymeric Platform for Lung Cancer Treatment

Overview

Journal Polymers (Basel)

Publisher MDPI

Date 2023 Jan 21

PMID 36679179

Authors

Atefeh Zarepour

Abdurrahim Can Egil

Melike Cokol Cakmak

Monireh Esmaeili Rad

Yuksel Cetin

Seyma Aydinlik

Gozde Ozaydin Ince

Ali Zarrabi

Affiliations

Soon will be listed here.

Abstract

Changes in weather conditions and lifestyle lead to an annual increase in the amount of lung cancer, and therefore it is one of the three most common types of cancer, making it important to find an appropriate treatment method. This research aims to introduce a new smart nano-drug delivery system with antibacterial and anticancer capabilities that could be applied for the treatment of lung cancer. It is composed of a niosomal carrier containing curcumin as an anticancer drug and is coated with a chitosan polymeric shell, alongside Rose Bengal (RB) as a photosensitizer with an antibacterial feature. The characterization results confirmed the successful fabrication of lipid-polymeric carriers with a size of nearly 80 nm and encapsulation efficiency of about 97% and 98% for curcumin and RB, respectively. It had the Korsmeyer-Peppas release pattern model with pH and temperature responsivity so that nearly 60% and 35% of RB and curcumin were released at 37 °C and pH 5.5. Moreover, it showed nearly 50% toxicity against lung cancer cells over 72 h and antibacterial activity against . Accordingly, this nanoformulation could be considered a candidate for the treatment of lung cancer; however, in vivo studies are needed for better confirmation.

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References

Almutairi F, Abd-Rabou A, Mohamed M . Raloxifene-encapsulated hyaluronic acid-decorated chitosan nanoparticles selectively induce apoptosis in lung cancer cells. Bioorg Med Chem. 2019; 27(8):1629-1638. DOI: 10.1016/j.bmc.2019.03.004. View

Shrestha A, Hamblin M, Kishen A . Photoactivated rose bengal functionalized chitosan nanoparticles produce antibacterial/biofilm activity and stabilize dentin-collagen. Nanomedicine. 2013; 10(3):491-501. PMC: 3966929. DOI: 10.1016/j.nano.2013.10.010. View

Kurosu M, Mitachi K, Yang J, Pershing E, Horowitz B, Wachter E . Antibacterial Activity of Pharmaceutical-Grade Rose Bengal: An Application of a Synthetic Dye in Antibacterial Therapies. Molecules. 2022; 27(1). PMC: 8746496. DOI: 10.3390/molecules27010322. View

Li Y, Wang J, Yang Y, Shi J, Zhang H, Yao X . A rose bengal/graphene oxide/PVA hybrid hydrogel with enhanced mechanical properties and light-triggered antibacterial activity for wound treatment. Mater Sci Eng C Mater Biol Appl. 2020; 118:111447. DOI: 10.1016/j.msec.2020.111447. View

Xie Y, Tuguntaev R, Mao C, Chen H, Tao Y, Wang S . Stimuli-responsive polymeric nanomaterials for rheumatoid arthritis therapy. Biophys Rep. 2023; 6(5):193-210. PMC: 10240797. DOI: 10.1007/s41048-020-00117-8. View

Kurniawan A, Gunawan F, Nugraha A, Ismadji S, Wang M . Biocompatibility and drug release behavior of curcumin conjugated gold nanoparticles from aminosilane-functionalized electrospun poly(N-vinyl-2-pyrrolidone) fibers. Int J Pharm. 2016; 516(1-2):158-169. DOI: 10.1016/j.ijpharm.2016.10.067. View

Islam S, Arnold L, Padhye R . Comparison and Characterisation of Regenerated Chitosan from 1-Butyl-3-methylimidazolium Chloride and Chitosan from Crab Shells. Biomed Res Int. 2015; 2015:874316. PMC: 4452278. DOI: 10.1155/2015/874316. View

Gottenbos B, Grijpma D, van der Mei H, Feijen J, Busscher H . Antimicrobial effects of positively charged surfaces on adhering Gram-positive and Gram-negative bacteria. J Antimicrob Chemother. 2001; 48(1):7-13. DOI: 10.1093/jac/48.1.7. View

Witika B, Bassey K, Demana P, Siwe-Noundou X, Poka M . Current Advances in Specialised Niosomal Drug Delivery: Manufacture, Characterization and Drug Delivery Applications. Int J Mol Sci. 2022; 23(17). PMC: 9455955. DOI: 10.3390/ijms23179668. View

10.

Nakonechny F, Barel M, David A, Koretz S, Litvak B, Ragozin E . Dark Antibacterial Activity of Rose Bengal. Int J Mol Sci. 2019; 20(13). PMC: 6651402. DOI: 10.3390/ijms20133196. View

11.

Paul D . Elaborations on the Higuchi model for drug delivery. Int J Pharm. 2010; 418(1):13-7. DOI: 10.1016/j.ijpharm.2010.10.037. View

12.

Kovaleva O, Romashin D, Zborovskaya I, Davydov M, Shogenov M, Gratchev A . Human Lung Microbiome on the Way to Cancer. J Immunol Res. 2019; 2019:1394191. PMC: 6710786. DOI: 10.1155/2019/1394191. View

13.

Aparajay P, Dev A . Functionalized niosomes as a smart delivery device in cancer and fungal infection. Eur J Pharm Sci. 2021; 168:106052. DOI: 10.1016/j.ejps.2021.106052. View

14.

Babu A, Amreddy N, Muralidharan R, Pathuri G, Gali H, Chen A . Chemodrug delivery using integrin-targeted PLGA-Chitosan nanoparticle for lung cancer therapy. Sci Rep. 2017; 7(1):14674. PMC: 5676784. DOI: 10.1038/s41598-017-15012-5. View

15.

Kurniawan A, Muneekaew S, Hung C, Chou S, Wang M . Modulated transdermal delivery of nonsteroidal anti-inflammatory drug by macroporous poly(vinyl alcohol)-graphene oxide nanocomposite films. Int J Pharm. 2019; 566:708-716. DOI: 10.1016/j.ijpharm.2019.06.029. View

16.

Hemati M, Haghiralsadat F, Yazdian F, Jafari F, Moradi A, Malekpour-Dehkordi Z . Development and characterization of a novel cationic PEGylated niosome-encapsulated forms of doxorubicin, quercetin and siRNA for the treatment of cancer by using combination therapy. Artif Cells Nanomed Biotechnol. 2018; 47(1):1295-1311. DOI: 10.1080/21691401.2018.1489271. View

17.

Hoshikawa A, Nagira M, Tane M, Fukushige K, Tagami T, Ozeki T . Preparation of Curcumin-Containing α-, β-, and γ-Cyclodextrin/Polyethyleneglycol-Conjugated Gold Multifunctional Nanoparticles and Their in Vitro Cytotoxic Effects on A549 Cells. Biol Pharm Bull. 2018; 41(6):908-914. DOI: 10.1248/bpb.b18-00010. View

18.

Lee R, Choi Y, Jeong M, Park Y, Motoyama K, Kim M . Hyaluronic Acid-Decorated Glycol Chitosan Nanoparticles for pH-Sensitive Controlled Release of Doxorubicin and Celecoxib in Nonsmall Cell Lung Cancer. Bioconjug Chem. 2020; 31(3):923-932. DOI: 10.1021/acs.bioconjchem.0c00048. View

19.

Das S, Bharadwaj P, Bilal M, Barani M, Rahdar A, Taboada P . Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis. Polymers (Basel). 2020; 12(6). PMC: 7362228. DOI: 10.3390/polym12061397. View

20.

Cui H, Siva S, Lin L . Ultrasound processed cuminaldehyde/2-hydroxypropyl-β-cyclodextrin inclusion complex: Preparation, characterization and antibacterial activity. Ultrason Sonochem. 2019; 56:84-93. DOI: 10.1016/j.ultsonch.2019.04.001. View