Magnetic Platelets As a Platform for Drug Delivery and Cell Trapping

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2023 Jan 21

PMID 36678843

Authors

Oksana A Mayorova

Olga I Gusliakova

Ekaterina S Prikhozhdenko

Roman A Verkhovskii

Daniil N Bratashov

Affiliations

Soon will be listed here.

Abstract

The possibility of using magnetically labeled blood cells as carriers is a novel approach in targeted drug-delivery systems, potentially allowing for improved bloodstream delivery strategies. Blood cells already meet the requirements of biocompatibility, safety from clotting and blockage of small vessels. It would solve the important problem of the patient's immune response to embedded foreign carriers. The high efficiency of platelet loading makes them promising research objects for the development of personalized drug-delivery systems. We are developing a new approach to use platelets decorated with magnetic nanoparticles as a targeted drug-delivery system, with a focus on bloodstream delivery. Platelets are non-nuclear blood cells and are of great importance in the pathogenesis of blood-clotting disorders. In addition, platelets are able to attach to circulating tumor cells. In this article, we studied the effect of platelets labeled with BSA-modified magnetic nanoparticles on healthy and cancer cells. This opens up broad prospects for future research based on the delivery of specific active substances by this method.

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References

Ye H, Tong J, Wu J, Xu X, Wu S, Tan B . Preclinical evaluation of recombinant human IFNα2b-containing magnetoliposomes for treating hepatocellular carcinoma. Int J Nanomedicine. 2014; 9:4533-50. PMC: 4184408. DOI: 10.2147/IJN.S67228. View

Sindeeva O, Verkhovskii R, Abdurashitov A, Voronin D, Gusliakova O, Kozlova A . Effect of Systemic Polyelectrolyte Microcapsule Administration on the Blood Flow Dynamics of Vital Organs. ACS Biomater Sci Eng. 2021; 6(1):389-397. DOI: 10.1021/acsbiomaterials.9b01669. View

Li N . Platelets in cancer metastasis: To help the "villain" to do evil. Int J Cancer. 2015; 138(9):2078-87. DOI: 10.1002/ijc.29847. View

Su Y, Xie Z, Kim G, Dong C, Yang J . Design strategies and applications of circulating cell-mediated drug delivery systems. ACS Biomater Sci Eng. 2015; 1(4):201-217. PMC: 4428174. DOI: 10.1021/ab500179h. View

Nosrati H, Sefidi N, Sharafi A, Danafar H, Manjili H . Bovine Serum Albumin (BSA) coated iron oxide magnetic nanoparticles as biocompatible carriers for curcumin-anticancer drug. Bioorg Chem. 2018; 76:501-509. DOI: 10.1016/j.bioorg.2017.12.033. View

Zhang L, Sang Y, Feng J, Li Z, Zhao A . Polysaccharide-based micro/nanocarriers for oral colon-targeted drug delivery. J Drug Target. 2016; 24(7):579-89. DOI: 10.3109/1061186X.2015.1128941. View

Biagiotti S, Rossi L, Bianchi M, Giacomini E, Pierige F, Serafini G . Immunophilin-loaded erythrocytes as a new delivery strategy for immunosuppressive drugs. J Control Release. 2011; 154(3):306-13. DOI: 10.1016/j.jconrel.2011.05.024. View

Tomaiuolo M, Litvinov R, Weisel J, Stalker T . Use of electron microscopy to study platelets and thrombi. Platelets. 2020; 31(5):580-588. PMC: 7332414. DOI: 10.1080/09537104.2020.1763939. View

Hamidi M, Zarrin A, Foroozesh M, Mohammadi-Samani S . Applications of carrier erythrocytes in delivery of biopharmaceuticals. J Control Release. 2007; 118(2):145-60. DOI: 10.1016/j.jconrel.2006.06.032. View

10.

Prikhozhdenko E, Gusliakova O, Kulikov O, Mayorova O, Shushunova N, Abdurashitov A . Target delivery of drug carriers in mice kidney glomeruli via renal artery. Balance between efficiency and safety. J Control Release. 2020; 329:175-190. DOI: 10.1016/j.jconrel.2020.11.051. View

11.

Santos-Martinez M, Tomaszewski K, Medina C, Bazou D, Gilmer J, Radomski M . Pharmacological characterization of nanoparticle-induced platelet microaggregation using quartz crystal microbalance with dissipation: comparison with light aggregometry. Int J Nanomedicine. 2015; 10:5107-19. PMC: 4540170. DOI: 10.2147/IJN.S84305. View

12.

Phanse Y, Ramer-Tait A, Friend S, Carrillo-Conde B, Lueth P, Oster C . Analyzing cellular internalization of nanoparticles and bacteria by multi-spectral imaging flow cytometry. J Vis Exp. 2012; (64):e3884. PMC: 3471309. DOI: 10.3791/3884. View

13.

Chan M, Armstrong P, Papalia F, Kirkby N, Warner T . Optical multichannel (optimul) platelet aggregometry in 96-well plates as an additional method of platelet reactivity testing. Platelets. 2011; 22(7):485-94. DOI: 10.3109/09537104.2011.592958. View

14.

Hernandez-Oller L, Seras-Franzoso J, Andrade F, Rafael D, Abasolo I, Gener P . Extracellular Vesicles as Drug Delivery Systems in Cancer. Pharmaceutics. 2020; 12(12). PMC: 7761384. DOI: 10.3390/pharmaceutics12121146. View

15.

Xu P, Zuo H, Chen B, Wang R, Ahmed A, Hu Y . Doxorubicin-loaded platelets as a smart drug delivery system: An improved therapy for lymphoma. Sci Rep. 2017; 7:42632. PMC: 5309782. DOI: 10.1038/srep42632. View

16.

Reimer P, Balzer T . Ferucarbotran (Resovist): a new clinically approved RES-specific contrast agent for contrast-enhanced MRI of the liver: properties, clinical development, and applications. Eur Radiol. 2003; 13(6):1266-76. DOI: 10.1007/s00330-002-1721-7. View

17.

Easo S, Mohanan P . In vitro hematological and in vivo immunotoxicity assessment of dextran stabilized iron oxide nanoparticles. Colloids Surf B Biointerfaces. 2015; 134:122-30. DOI: 10.1016/j.colsurfb.2015.06.046. View

18.

Gusliakova O, Prikhozhdenko E, Plastun V, Mayorova O, Shushunova N, Abdurashitov A . Renal Artery Catheterization for Microcapsules' Targeted Delivery to the Mouse Kidney. Pharmaceutics. 2022; 14(5). PMC: 9144148. DOI: 10.3390/pharmaceutics14051056. View

19.

Itoh H, Sugimoto T . Systematic control of size, shape, structure, and magnetic properties of uniform magnetite and maghemite particles. J Colloid Interface Sci. 2003; 265(2):283-95. DOI: 10.1016/s0021-9797(03)00511-3. View

20.

Freedman J, Loscalzo J . Platelet-monocyte aggregates: bridging thrombosis and inflammation. Circulation. 2002; 105(18):2130-2. DOI: 10.1161/01.cir.0000017140.26466.f5. View