The Activity of Red Nigerian Propolis and Some of Its Components Against and

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2023 Jan 21

PMID 36677679

Authors

Samya S Alenezi

Naif D Alenezi

Godwin U Ebiloma

Manal J Natto

Marzuq A Ungogo

John O Igoli

Valerie A Ferro

Alexander I Gray

James Fearnley

Harry P de Koning

David G Watson

Affiliations

Soon will be listed here.

Abstract

Propolis is a resin that is gathered by bees from exudates produced by various plants. Its exact chemical composition depends on the plants available near the hive. Bees use propolis to coat the surfaces of the hive, where it acts as an anti-infective. Regardless of the chemical composition of propolis, it is always anti-protozoal, probably because protozoan parasites, particularly , are widespread in bee populations. The protozoa and cause disease in humans and/or animals. The existing drugs for treating these diseases are old and resistance is an increasingly severe problem. The many types of propolis present a rich source of anti-trypanosomal compounds-from a material gathered by bees in an environmentally friendly way. In the current work, red Nigerian propolis from Rivers State, Nigeria was tested against and and found to be highly active (EC 1.66 and 4.00 µg/mL, respectively). Four isoflavonoids, vestitol, neovestitol, 7-methylvestitol and medicarpin, were isolated from the propolis. The isolated compounds were also tested against and , and vestitol displayed the highest activity at 3.86 and 4.36 µg/mL, respectively. Activities against drug-resistant forms of and were similar to those against wild type.

Citing Articles

Anti- Potential of Vestitol Isolated from Lyophilized Red Propolis.

Sousa L, Amparo T, Souza G, Ferraz A, Fonseca K, Azevedo A Molecules. 2023; 28(23).

PMID: 38067542 PMC: 10708512. DOI: 10.3390/molecules28237812.

Attenuation of pathogenesis of Eimeria stiedae sporulated oocysts using Egyptian alginate propolis nanoparticles.

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