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Current Insights into Diagnosis, Prevention Strategies, Treatment, Therapeutic Targets, and Challenges of Monkeypox (Mpox) Infections in Human Populations

Overview
Journal Life (Basel)
Specialty Biology
Date 2023 Jan 21
PMID 36676198
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Abstract

In the wake of the emergence and worldwide respread of a viral infection called Monkeypox (Mpox), there is a serious threat to the health and safety of the global population. This viral infection was endemic to the western and central parts of Africa, but has recently spread out of this endemic area to various countries, including the United Kingdom (UK), Portugal, Spain, the United States of America (USA), Canada, Sweden, Belgium, Italy, Australia, Germany, France, the Netherlands, Israel, and Mexico. This is a timely review focusing on recent findings and developments in the epidemiology, clinical features, therapeutic targets, diagnosis, prevention mechanisms, research challenges and possible treatment for Mpox. To date (29 November 2022), there have been around 81,225 reported cases of Mpox. In most cases, this illness is mild; however, there is a fatality rate ranging from 1 to 10%, which might be increased due to associated complications and/or secondary infections. There is a real challenge in the diagnosis of Mpox, since its symptoms are very similar to those of other infections, including smallpox and chickenpox. Generally, to prevent/limit the risk and transmission of Mpox, the detection and isolation of infected individuals, as well as hand hygiene and cleanliness, are essential and effective approaches to control/combat this viral infection. Nevertheless, updated information about Mpox from different angles is lacking. Thus, this review provides updated and comprehensive information about the Mpox illness, which should highlight the global burden, pathogenicity, symptoms, diagnosis, prevention measures and possible treatment of this emerging disease.

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References
1.
Parker S, Chen N, Foster S, Hartzler H, Hembrador E, Hruby D . Evaluation of disease and viral biomarkers as triggers for therapeutic intervention in respiratory mousepox - an animal model of smallpox. Antiviral Res. 2012; 94(1):44-53. PMC: 3722602. DOI: 10.1016/j.antiviral.2012.02.005. View

2.
Petersen E, Kantele A, Koopmans M, Asogun D, Yinka-Ogunleye A, Ihekweazu C . Human Monkeypox: Epidemiologic and Clinical Characteristics, Diagnosis, and Prevention. Infect Dis Clin North Am. 2019; 33(4):1027-1043. PMC: 9533922. DOI: 10.1016/j.idc.2019.03.001. View

3.
Roess A, Monroe B, Kinzoni E, Gallagher S, Ibata S, Badinga N . Assessing the effectiveness of a community intervention for monkeypox prevention in the Congo basin. PLoS Negl Trop Dis. 2011; 5(10):e1356. PMC: 3196471. DOI: 10.1371/journal.pntd.0001356. View

4.
Marennikova S, Seluhina E, Malceva N, Cimiskjan K, Macevic G . Isolation and properties of the causal agent of a new variola-like disease (monkeypox) in man. Bull World Health Organ. 1972; 46(5):599-611. PMC: 2480798. View

5.
Miura F, van Ewijk C, Backer J, Xiridou M, Franz E, de Coul E . Estimated incubation period for monkeypox cases confirmed in the Netherlands, May 2022. Euro Surveill. 2022; 27(24). PMC: 9205160. DOI: 10.2807/1560-7917.ES.2022.27.24.2200448. View