Non- Species: Immune Response, Evasion Mechanisms, and New Plant-Derived Alternative Therapies

Fungal infections caused by species have become a constant threat to public health, especially for immunocompromised patients, who are considered susceptible to this type of opportunistic infections. is known as the most common etiological agent of candidiasis; however, other species, such as , , (previously known as ), , , and (previously named as ), have also gained great importance in recent years. The increasing frequency of the isolation of this non- species is associated with different factors, such as constant exposure to antifungal drugs, the use of catheters in hospitalized patients, cancer, age, and geographic distribution. The main concerns for the control of these pathogens include their ability to evade the mechanisms of action of different drugs, thus developing resistance to antifungal drugs, and it has also been shown that some of these species also manage to evade the host's immunity. These biological traits make candidiasis treatment a challenging task. In this review manuscript, a detailed update of the recent literature on the six most relevant non- species is provided, focusing on the immune response, evasion mechanisms, and new plant-derived compounds with antifungal properties.