A New Potential Therapeutic Target for Cancer in Ubiquitin-Like Proteins-UBL3

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Jan 21

PMID 36674743

Authors

Hengsen Zhang

Bin Chen

A S M Waliullah

Shuhei Aramaki

Yashuang Ping

Yusuke Takanashi

Chi Zhang

Qing Zhai

Jing Yan

Soho Oyama

Tomoaki Kahyo

Mitsutoshi Setou

Affiliations

Soon will be listed here.

Abstract

Ubiquitin-like proteins (Ubls) are involved in a variety of biological processes through the modification of proteins. Dysregulation of Ubl modifications is associated with various diseases, especially cancer. Ubiquitin-like protein 3 (UBL3), a type of Ubl, was revealed to be a key factor in the process of small extracellular vesicle (sEV) protein sorting and major histocompatibility complex class II ubiquitination. A variety of sEV proteins that affects cancer properties has been found to interact with UBL3. An increasing number of studies has implied that UBL3 expression affects cancer cell growth and cancer prognosis. In this review, we provide an overview of the relationship between various Ubls and cancers. We mainly introduce UBL3 and its functions and summarize the current findings of UBL3 and examine its potential as a therapeutic target in cancers.

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PMID: 38747592 PMC: 11188874. DOI: 10.1158/2767-9764.CRC-23-0528.

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