Effects of Mindfulness-Based Cognitive Therapy on Major Depressive Disorder with Multiple Episodes: A Systematic Review and Meta-Analysis

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2023 Jan 21

PMID 36674310

Authors

Hui-Wen Tseng

Fan-Hao Chou

Ching-Hsiu Chen

Yu-Ping Chang

Affiliations

Soon will be listed here.

Abstract

This study synthesizes the effect of mindfulness-based cognitive therapy (MBCT) on depression and suicidal ideation among patients with major depressive disorder (MDD). During treatment, patients with MDD may experience repeated episodes, negative counseling, and suicidal ideation, which can lead to further depression and ultimately affect quality of life. Recent studies have shown that MBCT can improve the level of depression and suicidal ideation in patients with MDD. A systematic review and meta-analysis of randomized controlled trials was conducted. The literature search for articles up to December 2021 was performed in the following electronic databases: Airiti Library, PsycINFO, CINAHL, Cochrane Library, PubMed/MEDLINE, ProQuest, and the Index of the Taiwan Periodical Literature System. Records were independently evaluated by two reviewers. Disagreements were resolved through consensus. The quality of study was evaluated using the Modified Jadad Scale score. A meta-analysis was performed using Review Manager Version 5.3.5 software with a random-effects model. Thirteen studies (1159 participants) investigating MBCT for patients with MDD were included. The MBCT sessions lasted 1.5-2.5 h and were delivered by therapists five times per week for 8 weeks. The meta-effects of MBCT among patients with MDD showed significant improvement in depression and suicidal ideation. Future research should evaluate the long-term effects of MBCT. MBCT is relatively convenient and effective for preventing and alleviating depression and suicidal ideation. Further research can provide detailed suggestions for effective MBCT implementation.

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References

Hepburn S, Crane C, Barnhofer T, Duggan D, Fennell M, Williams J . Mindfulness-based cognitive therapy may reduce thought suppression in previously suicidal participants: findings from a preliminary study. Br J Clin Psychol. 2009; 48(Pt 2):209-15. DOI: 10.1348/014466509X414970. View

Blumberg M, Vaccarino S, McInerney S . Procognitive Effects of Antidepressants and Other Therapeutic Agents in Major Depressive Disorder: A Systematic Review. J Clin Psychiatry. 2020; 81(4). DOI: 10.4088/JCP.19r13200. View

Park E, Jung M . The impact of major depressive disorder on adaptive function: A retrospective observational study. Medicine (Baltimore). 2019; 98(52):e18515. PMC: 6946334. DOI: 10.1097/MD.0000000000018515. View

Crane C, Williams J . Factors Associated with Attrition from Mindfulness-Based Cognitive Therapy in Patients with a History of Suicidal Depression. Mindfulness (N Y). 2010; 1(1):10-20. PMC: 2987524. DOI: 10.1007/s12671-010-0003-8. View

van der Velden A, Kuyken W, Wattar U, Crane C, Pallesen K, Dahlgaard J . A systematic review of mechanisms of change in mindfulness-based cognitive therapy in the treatment of recurrent major depressive disorder. Clin Psychol Rev. 2015; 37:26-39. DOI: 10.1016/j.cpr.2015.02.001. View

Kuyken W, Warren F, Taylor R, Whalley B, Crane C, Bondolfi G . Efficacy of Mindfulness-Based Cognitive Therapy in Prevention of Depressive Relapse: An Individual Patient Data Meta-analysis From Randomized Trials. JAMA Psychiatry. 2016; 73(6):565-74. PMC: 6640038. DOI: 10.1001/jamapsychiatry.2016.0076. View

Egger M, Davey Smith G, Schneider M, Minder C . Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997; 315(7109):629-34. PMC: 2127453. DOI: 10.1136/bmj.315.7109.629. View

Teasdale J, Segal Z, Williams J, Ridgeway V, Soulsby J, Lau M . Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. J Consult Clin Psychol. 2000; 68(4):615-23. DOI: 10.1037//0022-006x.68.4.615. View

Oremus M, Wolfson C, Perrault A, Demers L, Momoli F, Moride Y . Interrater reliability of the modified Jadad quality scale for systematic reviews of Alzheimer's disease drug trials. Dement Geriatr Cogn Disord. 2001; 12(3):232-6. DOI: 10.1159/000051263. View

10.

Steinert C, Hofmann M, Kruse J, Leichsenring F . Relapse rates after psychotherapy for depression - stable long-term effects? A meta-analysis. J Affect Disord. 2014; 168:107-18. DOI: 10.1016/j.jad.2014.06.043. View

11.

Barnhofer T, Crane C, Hargus E, Amarasinghe M, Winder R, Williams J . Mindfulness-based cognitive therapy as a treatment for chronic depression: A preliminary study. Behav Res Ther. 2009; 47(5):366-73. PMC: 2866254. DOI: 10.1016/j.brat.2009.01.019. View

12.

Higgins J, Thompson S, Deeks J, Altman D . Measuring inconsistency in meta-analyses. BMJ. 2003; 327(7414):557-60. PMC: 192859. DOI: 10.1136/bmj.327.7414.557. View

13.

Liberati A, Altman D, Tetzlaff J, Mulrow C, Gotzsche P, Ioannidis J . The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009; 339:b2700. PMC: 2714672. DOI: 10.1136/bmj.b2700. View

14.

Hargus E, Crane C, Barnhofer T, Williams J . Effects of mindfulness on meta-awareness and specificity of describing prodromal symptoms in suicidal depression. Emotion. 2010; 10(1):34-42. PMC: 3933215. DOI: 10.1037/a0016825. View

15.

Fragkos K, Tsagris M, Frangos C . Publication Bias in Meta-Analysis: Confidence Intervals for Rosenthal's Fail-Safe Number. Int Sch Res Notices. 2016; 2014:825383. PMC: 4897051. DOI: 10.1155/2014/825383. View

16.

Nock M, Hwang I, Sampson N, Kessler R, Angermeyer M, Beautrais A . Cross-national analysis of the associations among mental disorders and suicidal behavior: findings from the WHO World Mental Health Surveys. PLoS Med. 2009; 6(8):e1000123. PMC: 2717212. DOI: 10.1371/journal.pmed.1000123. View

17.

Williams J, Russell I, Crane C, Russell D, Whitaker C, Duggan D . Staying well after depression: trial design and protocol. BMC Psychiatry. 2010; 10:23. PMC: 2859374. DOI: 10.1186/1471-244X-10-23. View

18.

Tomazic T, celofiga A . The Role of Different Behavioral and Psychosocial Factors in the Context of Pharmaceutical Cognitive Enhancers' Misuse. Healthcare (Basel). 2022; 10(6). PMC: 9222761. DOI: 10.3390/healthcare10060972. View

19.

Forkmann T, Wichers M, Geschwind N, Peeters F, van Os J, Mainz V . Effects of mindfulness-based cognitive therapy on self-reported suicidal ideation: results from a randomised controlled trial in patients with residual depressive symptoms. Compr Psychiatry. 2014; 55(8):1883-90. DOI: 10.1016/j.comppsych.2014.08.043. View

20.

Zhang B, Fu W, Guo Y, Chen Y, Jiang C, Li X . Effectiveness of mindfulness-based cognitive therapy against suicidal ideation in patients with depression: A systematic review and meta-analysis. J Affect Disord. 2022; 319:655-662. DOI: 10.1016/j.jad.2022.09.091. View