High-Frequency (30 MHz-6 GHz) Breast Tissue Characterization Stabilized by Suction Force for Intraoperative Tumor Margin Assessment

Overview

Journal Diagnostics (Basel)

Specialty Radiology

Date 2023 Jan 21

PMID 36672989

Authors

Hadi Mokhtari Dowlatabad

Amir Mamdouh

Narges Yousefpour

Reihane Mahdavi

Ashkan Zandi

Parisa Hoseinpour

Seyed Mohammad Sadegh Moosavi-Kiasari

Fereshte Abbasvandi

Yasin Kordehlachin

Mohammad Parniani

Karim Mohammadpour-Aghdam

Pooya Faranoush

Mohammad Reza Foroughi-Gilvaee

Mohammad Abdolahad

Affiliations

Soon will be listed here.

Abstract

A gigahertz (GHz) range antenna formed by a coaxial probe has been applied for sensing cancerous breast lesions in the scanning platform with the assistance of a suction tube. The sensor structure was a planar central layer and a metallic sheath of size of 3 cm connected to a network analyzer (keySight FieldFox N9918A) with operational bandwidth up to 26.5 GHz. Cancer tumor cells have significantly higher water content (as a dipolar molecule) than normal breast cells, changing their polarization responses and dielectric losses to incoming GHz-based stimulation. Principal component analysis named , related to the dispersion ratio of the input signal, is used as a parameter to identify malignant tumor cells in a mouse model (in vivo) and tumor specimens of breast cancer patients (in vitro) (both central and marginal parts). The results showed that values in the frequency range from 5 to 6 GHz were significantly higher in cancer-involved breast lesions. Histopathological analysis was the gold standard for achieving the calibration to distinguish normal from cancerous lesions. Our calibration on tumor specimens presented 82% positive predictive value (PPV), 100% negative predictive value (NPV), and 86% accuracy. Our goal is to apply this system as an in vivo non-invasive tumor margin scanner after further investigations in the future.

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