Plant Exosome-like Nanoparticles As Biological Shuttles for Transdermal Drug Delivery

Overview

Journal Bioengineering (Basel)

Date 2023 Jan 21

PMID 36671676

Authors

Ye Wang

Yongsheng Wei

Hui Liao

Hongwei Fu

Xiaobin Yang

Qi Xiang

Shu Zhang

Affiliations

Soon will be listed here.

Abstract

Exosomes act as emerging transdermal drug delivery vehicles with high deformability and excellent permeability, which can be used to deliver various small-molecule drugs and macromolecular drugs and increase the transdermal and dermal retention of drugs, improving the local efficacy and drug delivery compliance. At present, there are many studies on the use of plant exosome-like nanoparticles (PELNVs) as drug carriers. In this review, the source, extraction, isolation, and chemical composition of plant exosomes are reviewed, and the research progress on PELNVs as drug delivery systems in transdermal drug delivery systems in recent years has elucidated the broad application prospect of PELNVs.

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References

Hannafon B, Ding W . Intercellular communication by exosome-derived microRNAs in cancer. Int J Mol Sci. 2013; 14(7):14240-69. PMC: 3742242. DOI: 10.3390/ijms140714240. View

Skotland T, Hessvik N, Sandvig K, Llorente A . Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology. J Lipid Res. 2018; 60(1):9-18. PMC: 6314266. DOI: 10.1194/jlr.R084343. View

Najahi-Missaoui W, Arnold R, Cummings B . Safe Nanoparticles: Are We There Yet?. Int J Mol Sci. 2021; 22(1). PMC: 7794803. DOI: 10.3390/ijms22010385. View

Sriwastva M, Deng Z, Wang B, Teng Y, Kumar A, Sundaram K . Exosome-like nanoparticles from Mulberry bark prevent DSS-induced colitis via the AhR/COPS8 pathway. EMBO Rep. 2022; 23(3):e53365. PMC: 8892346. DOI: 10.15252/embr.202153365. View

Fusar-Poli L, Vozza L, Gabbiadini A, Vanella A, Concas I, Tinacci S . Curcumin for depression: a meta-analysis. Crit Rev Food Sci Nutr. 2019; 60(15):2643-2653. DOI: 10.1080/10408398.2019.1653260. View

Mu H, Holm R . Solid lipid nanocarriers in drug delivery: characterization and design. Expert Opin Drug Deliv. 2018; 15(8):771-785. DOI: 10.1080/17425247.2018.1504018. View

Raimondo S, Naselli F, Fontana S, Monteleone F, Lo Dico A, Saieva L . Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death. Oncotarget. 2015; 6(23):19514-27. PMC: 4637302. DOI: 10.18632/oncotarget.4004. View

Theek B, Baues M, Ojha T, Mockel D, Veettil S, Steitz J . Sonoporation enhances liposome accumulation and penetration in tumors with low EPR. J Control Release. 2016; 231:77-85. PMC: 5404719. DOI: 10.1016/j.jconrel.2016.02.021. View

Skryabin G, Komelkov A, Savelyeva E, Tchevkina E . Lipid Rafts in Exosome Biogenesis. Biochemistry (Mosc). 2020; 85(2):177-191. DOI: 10.1134/S0006297920020054. View

10.

Wubbolts R, Leckie R, Veenhuizen P, Schwarzmann G, Mobius W, Hoernschemeyer J . Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation. J Biol Chem. 2003; 278(13):10963-72. DOI: 10.1074/jbc.M207550200. View

11.

Zhang Y, Liu Y, Liu H, Tang W . Exosomes: biogenesis, biologic function and clinical potential. Cell Biosci. 2019; 9:19. PMC: 6377728. DOI: 10.1186/s13578-019-0282-2. View

12.

Rupert D, Claudio V, Lasser C, Bally M . Methods for the physical characterization and quantification of extracellular vesicles in biological samples. Biochim Biophys Acta Gen Subj. 2016; 1861(1 Pt A):3164-3179. DOI: 10.1016/j.bbagen.2016.07.028. View

13.

Gauvreau M, Cote M, Bourgeois-Daigneault M, Rivard L, Xiu F, Brunet A . Sorting of MHC class II molecules into exosomes through a ubiquitin-independent pathway. Traffic. 2009; 10(10):1518-27. DOI: 10.1111/j.1600-0854.2009.00948.x. View

14.

Liga A, Vliegenthart A, Oosthuyzen W, Dear J, Kersaudy-Kerhoas M . Exosome isolation: a microfluidic road-map. Lab Chip. 2015; 15(11):2388-94. DOI: 10.1039/c5lc00240k. View

15.

Ciotti S, Weiner N . Follicular liposomal delivery systems. J Liposome Res. 2003; 12(1-2):143-8. DOI: 10.1081/lpr-120004787. View

16.

Mitchell M, Billingsley M, Haley R, Wechsler M, Peppas N, Langer R . Engineering precision nanoparticles for drug delivery. Nat Rev Drug Discov. 2020; 20(2):101-124. PMC: 7717100. DOI: 10.1038/s41573-020-0090-8. View

17.

LaVan D, McGuire T, Langer R . Small-scale systems for in vivo drug delivery. Nat Biotechnol. 2003; 21(10):1184-91. DOI: 10.1038/nbt876. View

18.

Urzi O, Gasparro R, Rabienezhad Ganji N, Alessandro R, Raimondo S . Plant-RNA in Extracellular Vesicles: The Secret of Cross-Kingdom Communication. Membranes (Basel). 2022; 12(4). PMC: 9028404. DOI: 10.3390/membranes12040352. View

19.

Severino P, da Silva C, Andrade L, de Lima Oliveira D, Campos J, Souto E . Alginate Nanoparticles for Drug Delivery and Targeting. Curr Pharm Des. 2019; 25(11):1312-1334. DOI: 10.2174/1381612825666190425163424. View

20.

Lynch S, Santos S, Campbell E, Nimmo A, Botting C, Prescott A . Novel MHC class I structures on exosomes. J Immunol. 2009; 183(3):1884-91. DOI: 10.4049/jimmunol.0900798. View