Genetic Predisposition to Neurological Complications in Patients with COVID-19

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2023 Jan 21

PMID 36671517

Authors

Nikhil Shri Sahajpal

Alex R Hastie

Maximilian Schieck

Ashis K Mondal

Marc Felde

Caspar I van der Made

Janet S Chou

Adrienne G Randolph

Thomas Illig

Michael C Zody

Catherine A Brownstein

Alan H Beggs

Alexander Hoischen

Alka Chaubey

Ravindra Kolhe

Affiliations

Soon will be listed here.

Abstract

Several studies have identified rare and common genetic variants associated with severe COVID-19, but no study has reported genetic determinants as predisposition factors for neurological complications. In this report, we identified rare/unique structural variants (SVs) implicated in neurological functions in two individuals with neurological manifestations of COVID-19. This report highlights the possible genetic link to the neurological symptoms with COVID-19 and calls for a collective effort to study these cohorts for a possible genetic linkage.

References

Coutelier M, Burglen L, Mundwiller E, Abada-Bendib M, Rodriguez D, Chantot-Bastaraud S . GRID2 mutations span from congenital to mild adult-onset cerebellar ataxia. Neurology. 2015; 84(17):1751-9. DOI: 10.1212/WNL.0000000000001524. View

Ishihara-Paul L, Hulihan M, Kachergus J, Upmanyu R, Warren L, Amouri R . PINK1 mutations and parkinsonism. Neurology. 2008; 71(12):896-902. PMC: 2676945. DOI: 10.1212/01.wnl.0000323812.40708.1f. View

Yoshii S, Kishi C, Ishihara N, Mizushima N . Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane. J Biol Chem. 2011; 286(22):19630-40. PMC: 3103342. DOI: 10.1074/jbc.M110.209338. View

Sun M, Latourelle J, Wooten G, Lew M, Klein C, Shill H . Influence of heterozygosity for parkin mutation on onset age in familial Parkinson disease: the GenePD study. Arch Neurol. 2006; 63(6):826-32. DOI: 10.1001/archneur.63.6.826. View

Takayama C, Nakagawa S, Watanabe M, Mishina M, Inoue Y . Light- and electron-microscopic localization of the glutamate receptor channel delta 2 subunit in the mouse Purkinje cell. Neurosci Lett. 1995; 188(2):89-92. DOI: 10.1016/0304-3940(95)11403-j. View

Hills L, Masri A, Konno K, Kakegawa W, Lam A, Lim-Melia E . Deletions in GRID2 lead to a recessive syndrome of cerebellar ataxia and tonic upgaze in humans. Neurology. 2013; 81(16):1378-86. PMC: 3806907. DOI: 10.1212/WNL.0b013e3182a841a3. View

Meinhardt J, Radke J, Dittmayer C, Franz J, Thomas C, Mothes R . Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19. Nat Neurosci. 2020; 24(2):168-175. DOI: 10.1038/s41593-020-00758-5. View

Khaddaj-Mallat R, Aldib N, Bernard M, Paquette A, Ferreira A, Lecordier S . SARS-CoV-2 deregulates the vascular and immune functions of brain pericytes via Spike protein. Neurobiol Dis. 2021; 161:105561. PMC: 8590447. DOI: 10.1016/j.nbd.2021.105561. View

Spudich S, Nath A . Nervous system consequences of COVID-19. Science. 2022; 375(6578):267-269. DOI: 10.1126/science.abm2052. View

10.

Sahajpal N, Jill Lai C, Hastie A, Mondal A, Dehkordi S, van der Made C . Optical genome mapping identifies rare structural variations as predisposition factors associated with severe COVID-19. iScience. 2022; 25(2):103760. PMC: 8744399. DOI: 10.1016/j.isci.2022.103760. View

11.

Sa M, Mirza L, Carter M, Carlton Jones L, Gowda V, Handforth J . Systemic Inflammation Is Associated With Neurologic Involvement in Pediatric Inflammatory Multisystem Syndrome Associated With SARS-CoV-2. Neurol Neuroimmunol Neuroinflamm. 2021; 8(4). PMC: 8054962. DOI: 10.1212/NXI.0000000000000999. View

12.

Lubbe S, Bustos B, Hu J, Krainc D, Joseph T, Hehir J . Assessing the relationship between monoallelic PRKN mutations and Parkinson's risk. Hum Mol Genet. 2021; 30(1):78-86. PMC: 8033143. DOI: 10.1093/hmg/ddaa273. View

13.

Shimokaze T, Kato M, Yoshimura Y, Takahashi Y, Hayasaka K . A case of acute cerebellitis accompanied by autoantibodies against glutamate receptor delta2. Brain Dev. 2006; 29(4):224-6. DOI: 10.1016/j.braindev.2006.08.011. View

14.

Cohen M, Eichel R, Steiner-Birmanns B, Janah A, Ioshpa M, Bar-Shalom R . A case of probable Parkinson's disease after SARS-CoV-2 infection. Lancet Neurol. 2020; 19(10):804-805. PMC: 7494295. DOI: 10.1016/S1474-4422(20)30305-7. View

15.

Strafella C, Caputo V, Termine A, Barati S, Gambardella S, Borgiani P . Analysis of Genetic Variability among Populations Highlights a Possible Link with COVID-19-Related Neurological Complications. Genes (Basel). 2020; 11(7). PMC: 7397291. DOI: 10.3390/genes11070741. View

16.

Najjar S, Najjar A, Chong D, Pramanik B, Kirsch C, Kuzniecky R . Central nervous system complications associated with SARS-CoV-2 infection: integrative concepts of pathophysiology and case reports. J Neuroinflammation. 2020; 17(1):231. PMC: 7406702. DOI: 10.1186/s12974-020-01896-0. View

17.

Oliveira S, Scott W, Martin E, Nance M, Watts R, Hubble J . Parkin mutations and susceptibility alleles in late-onset Parkinson's disease. Ann Neurol. 2003; 53(5):624-9. DOI: 10.1002/ana.10524. View

18.

Maier A, Klopocki E, Horn D, Tzschach A, Holm T, Meyer R . De novo partial deletion in GRID2 presenting with complicated spastic paraplegia. Muscle Nerve. 2013; 49(2):289-92. DOI: 10.1002/mus.24096. View

19.

Martin M, Paes V, Cardoso E, Passos Neto C, Kanamura C, da Costa Leite C . Postmortem brain 7T MRI with minimally invasive pathological correlation in deceased COVID-19 subjects. Insights Imaging. 2022; 13(1):7. PMC: 8760871. DOI: 10.1186/s13244-021-01144-w. View

20.

Magusali N, Graham A, Piers T, Panichnantakul P, Yaman U, Shoai M . A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene. Brain. 2021; 144(12):3727-3741. PMC: 8500089. DOI: 10.1093/brain/awab337. View