The Therapeutic Alliance Between Pomegranate and Health Emphasizing on Anticancer Properties

Overview

Journal Antioxidants (Basel)

Date 2023 Jan 21

PMID 36671048

Authors

Panagiota D Pantiora

Alexandros I Balaouras

Ioanna K Mina

Christoforos I Freris

Athanasios C Pappas

Georgios P Danezis

Evangelos Zoidis

Constantinos A Georgiou

Affiliations

Soon will be listed here.

Abstract

Pomegranate is a fruit bearing-plant that is well known for its medicinal properties. Pomegranate is a good source of phenolic acids, tannins, and flavonoids. Pomegranate juice and by-products have attracted the scientific interest due to their potential health benefits. Currently, the medical community has showed great interest in exploiting pomegranate potential as a protective agent against several human diseases including cancer. This is demonstrated by the fact that there are more than 800 reports in the literature reporting pomegranate's anticancer properties. This review is an update on the research outcomes of pomegranate's potential against different types of human diseases, emphasizing on cancer. In addition, perspectives of potential applications of pomegranate, as a natural additive aiming to improve the quality of animal products, are discussed.

Citing Articles

Effects of Pomegranate Seed Oil on Lower Extremity Ischemia-Reperfusion Damage: Insights into Oxidative Stress, Inflammation, and Cell Death.

Bozok U, Ergorun A, Kucuk A, Yigman Z, Dursun A, Arslan M Medicina (Kaunas). 2025; 61(2).

PMID: 40005329 PMC: 11857112. DOI: 10.3390/medicina61020212.

Contemporary Strategies for Clinical Chemoprevention of Localized Prostate Cancer.

Kumar N Cancer Control. 2024; 31:10732748241302863.

PMID: 39573923 PMC: 11583501. DOI: 10.1177/10732748241302863.

Chitosan/Pomegranate Seed Oil Emulgel Composition as a New Strategy for Dermal Delivery of Hydrocortisone.

Baginska Z, Paczkowska-Walendowska M, Basa A, Rachalewski M, Lendzion K, Cielecka-Piontek J Int J Mol Sci. 2024; 25(7).

PMID: 38612575 PMC: 11012218. DOI: 10.3390/ijms25073765.

A review of experimental and clinical studies on the therapeutic effects of pomegranate () on non-alcoholic fatty liver disease: Focus on oxidative stress and inflammation.

Zamanian M, Sadeghi Ivraghi M, Khachatryan L, Vadiyan D, Bali H, Golmohammadi M Food Sci Nutr. 2023; 11(12):7485-7503.

PMID: 38107091 PMC: 10724645. DOI: 10.1002/fsn3.3713.

Influence of Pomegranate Appearance Attributes on Consumer Choice, and Identification of Barriers and Drivers for Consumption.

Pons-Gomez A, Albert-Sidro C, Bartual J, Yuste F, Besada C Foods. 2023; 12(20).

PMID: 37893696 PMC: 10606882. DOI: 10.3390/foods12203803.

References

Lee S, Wu Y, Chien L, Chen S, Tzeng Y, Wu T . Proteomic exploration of the impacts of pomegranate fruit juice on the global gene expression of prostate cancer cell. Proteomics. 2012; 12(21):3251-62. DOI: 10.1002/pmic.201200084. View

Khan A, Alanazi A, Alsaif N, Wani T, Bhat M . Pomegranate peel induced biogenic synthesis of silver nanoparticles and their multifaceted potential against intracellular pathogen and cancer. Saudi J Biol Sci. 2021; 28(8):4191-4200. PMC: 8325005. DOI: 10.1016/j.sjbs.2021.06.022. View

Afaq F, Katiyar S . Polyphenols: skin photoprotection and inhibition of photocarcinogenesis. Mini Rev Med Chem. 2011; 11(14):1200-15. PMC: 3288507. DOI: 10.2174/13895575111091200. View

Sahin B, Aygun A, Gunduz H, Sahin K, Demir E, Akocak S . Cytotoxic effects of platinum nanoparticles obtained from pomegranate extract by the green synthesis method on the MCF-7 cell line. Colloids Surf B Biointerfaces. 2017; 163:119-124. DOI: 10.1016/j.colsurfb.2017.12.042. View

Albrecht M, Jiang W, Kumi-Diaka J, Lansky E, Gommersall L, Patel A . Pomegranate extracts potently suppress proliferation, xenograft growth, and invasion of human prostate cancer cells. J Med Food. 2004; 7(3):274-83. DOI: 10.1089/jmf.2004.7.274. View

Wang L, Ho J, Glackin C, Martins-Green M . Specific pomegranate juice components as potential inhibitors of prostate cancer metastasis. Transl Oncol. 2012; 5(5):344-55. PMC: 3470115. DOI: 10.1593/tlo.12190. View

Sharma P, McClees S, Afaq F . Pomegranate for Prevention and Treatment of Cancer: An Update. Molecules. 2017; 22(1). PMC: 5560105. DOI: 10.3390/molecules22010177. View

Paller C, Pantuck A, Carducci M . A review of pomegranate in prostate cancer. Prostate Cancer Prostatic Dis. 2017; 20(3):265-270. PMC: 5555799. DOI: 10.1038/pcan.2017.19. View

Seidi K, Jahanban-Esfahlan R, Abasi M, Mesgari Abbasi M . Anti Tumoral Properties of Punica granatum (Pomegranate) Seed Extract in Different Human Cancer Cells. Asian Pac J Cancer Prev. 2016; 17(3):1119-22. DOI: 10.7314/apjcp.2016.17.3.1119. View

10.

Marin D, Aleman A, Sanchez-Faure A, Montero P, Gomez-Guillen M . Freeze-dried phosphatidylcholine liposomes encapsulating various antioxidant extracts from natural waste as functional ingredients in surimi gels. Food Chem. 2017; 245:525-535. DOI: 10.1016/j.foodchem.2017.10.141. View

11.

Nasser M, Damaj Z, Hijazi A, Merah O, Al-Khatib B, Hijazi N . Pomegranate Juice Extract Decreases Cisplatin Toxicity on Peripheral Blood Mononuclear Cells. Medicines (Basel). 2020; 7(10). PMC: 7602563. DOI: 10.3390/medicines7100066. View

12.

Peng S, Lin L, Chen S, Farooqi A, Cheng Y, Tang J . Pomegranate Extract (POMx) Induces Mitochondrial Dysfunction and Apoptosis of Oral Cancer Cells. Antioxidants (Basel). 2021; 10(7). PMC: 8301084. DOI: 10.3390/antiox10071117. View

13.

Peng S, Hsiao C, Lan T, Yen C, Farooqi A, Cheng C . Pomegranate extract inhibits migration and invasion of oral cancer cells by downregulating matrix metalloproteinase-2/9 and epithelial-mesenchymal transition. Environ Toxicol. 2020; 35(6):673-682. DOI: 10.1002/tox.22903. View

14.

Turkyilmaz M, Tagi S, Dereli U, Ozkan M . Effects of various pressing programs and yields on the antioxidant activity, antimicrobial activity, phenolic content and colour of pomegranate juices. Food Chem. 2013; 138(2-3):1810-8. DOI: 10.1016/j.foodchem.2012.11.100. View

15.

Seeram N, Aronson W, Zhang Y, Henning S, Moro A, Lee R . Pomegranate ellagitannin-derived metabolites inhibit prostate cancer growth and localize to the mouse prostate gland. J Agric Food Chem. 2007; 55(19):7732-7. DOI: 10.1021/jf071303g. View

16.

Nair V, Dai Z, Khan M, Ciolino H . Pomegranate extract induces cell cycle arrest and alters cellular phenotype of human pancreatic cancer cells. Anticancer Res. 2011; 31(9):2699-704. View

17.

Wang P, Zhang Q, Hou H, Liu Z, Wang L, Rasekhmagham R . The effects of pomegranate supplementation on biomarkers of inflammation and endothelial dysfunction: A meta-analysis and systematic review. Complement Ther Med. 2020; 49:102358. DOI: 10.1016/j.ctim.2020.102358. View

18.

Hasheminezhad S, Boozari M, Iranshahi M, Yazarlu O, Sahebkar A, Hasanpour M . A mechanistic insight into the biological activities of urolithins as gut microbial metabolites of ellagitannins. Phytother Res. 2021; 36(1):112-146. DOI: 10.1002/ptr.7290. View

19.

Banerjee S, Kambhampati S, Haque I, Banerjee S . Pomegranate sensitizes Tamoxifen action in ER-α positive breast cancer cells. J Cell Commun Signal. 2011; 5(4):317-24. PMC: 3245758. DOI: 10.1007/s12079-011-0138-y. View

20.

Ai Tran H, Bae S, Song B, Lee B, Bae Y, Kim Y . Pomegranate (Punica granatum) seed linolenic acid isomers: concentration-dependent modulation of estrogen receptor activity. Endocr Res. 2010; 35(1):1-16. DOI: 10.3109/07435800903524161. View