Harnessing Redox Disruption to Treat Human Herpesvirus 8 (HHV-8) Related Malignancies

Overview

Journal Antioxidants (Basel)

Date 2023 Jan 21

PMID 36670946

Authors

Adelie Gothland

Aude Jary

Philippe Grange

Valentin Leducq

Laurianne Beauvais-Remigereau

Nicolas Dupin

Anne-Genevieve Marcelin

Vincent Calvez

Affiliations

Soon will be listed here.

Abstract

Reprogrammed metabolism is regarded as a hallmark of cancer and offers a selective advantage to tumor cells during carcinogenesis. The redox equilibrium is necessary for growth, spread and the antioxidant pathways are boosted following Reactive Oxygen Species (ROS) production to prevent cell damage in tumor cells. Human herpesvirus 8 (HHV-8), the etiologic agent of Kaposi sarcoma KS and primary effusion lymphoma (PEL), is an oncogenic virus that disrupts cell survival-related molecular signaling pathways leading to immune host evasion, cells growths, angiogenesis and inflammatory tumor-environment. We recently reported that primaquine diphosphate causes cell death by apoptosis in HHV-8 infected PEL cell lines in vivo and exhibits therapeutic anti-tumor activity in mice models and advanced KS. Our findings also suggest that the primaquine-induced apoptosis in PEL cells is mostly influenced by ROS production and targeting the redox balance could be a new approach to treat HHV-8 related diseases. In this review, we summarized the knowledge about the influence of ROS in cancer development; more specifically, the proof of evidence from our work and from the literature that redox pathways are important for the development of HHV-8 pathologies.

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