DNA Damage As a Mechanistic Link Between Air Pollution and Obesity?

Overview

Journal Medicines (Basel)

Specialty Pharmacology

Date 2023 Jan 20

PMID 36662488

Authors

Abdelaziz Ghanemi

Mayumi Yoshioka

Jonny St-Amand

Affiliations

Soon will be listed here.

Abstract

It has been shown that the risk of developing obesity, a serious modern health problem, increases with air pollution. However, the molecular links are yet to be fully elucidated. Herein, we propose a hypothesis via which air pollution-induced DNA damage would be the mechanistic link between air pollution and the enhanced risk of obesity and overweight. Indeed, whereas air pollution leads to DNA damage, DNA damage results in inflammation, oxidative stress and metabolic impairments that could be behind energy balance changes contributing to obesity. Such thoughts, worth exploring, seems an important starting point to better understand the impact of air pollution on obesity development independently from the two main energy balance pillars that are diet and physical activity. This could possibly lead to new applications both for therapies as well as for policies and regulations.

Citing Articles

Secreted Protein Acidic and Rich in Cysteine ()-Mediated Exercise Effects: Illustrative Molecular Pathways against Various Diseases.

Ghanemi A, Yoshioka M, St-Amand J Diseases. 2023; 11(1).

PMID: 36810547 PMC: 9944512. DOI: 10.3390/diseases11010033.

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