Highly Thermally Resistant Bisamide Gelators As Pharmaceutical Crystallization Media

Overview

Journal Gels

Date 2023 Jan 20

PMID 36661796

Authors

Ivan Torres-Moya

Abelardo Sanchez

Basanta Saikia

Dmitry S Yufit

Pilar Prieto

Jose Ramon Carrillo

Jonathan W Steed

Affiliations

Soon will be listed here.

Abstract

Three simple bisamide derivatives (, and ) with different structural modifications were synthesized with easy synthetic procedures in order to test their gel behaviour. The outcomes showed that hydrogen bonding was essential in gel formation; for this reason, only provided satisfactory gels. The presence of methoxy groups in and the alkyl chains in hindered the hydrogen bonding between N-H and C=O that occurred . In addition, provided thermally and mechanical stable gels, as confirmed with T and rheology experiments. The gels of were also responsive under pH stimuli and were employed as a vehicle for drug crystallization, causing a change in polymorphism in the presence of flufenamic acid and therefore providing the most thermodynamically stable form III compared with metastable form IV obtained from solution crystallization.

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