Phase Diagrams of PEG + lithium Citrate + water ATPSs, and the Partitioning of Salbutamol at T = 298.15 K

Overview

Journal Sci Rep

Specialty Science

Date 2023 Jan 19

PMID 36658224

Authors

Ebrahim Nemati-Kande

Zolfa Azizi

Marziyeh Mokarizadeh

Affiliations

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Abstract

Salbutamol is a drug used to treat the pulmonary diseases by ameliorate the medium and large airways in the lungs. Partitioning of salbutamol drug on the aqueous two-phase systems (ATPSs) of PEG + trilithium citrate + water was determined at T = 298.15 K. The effect of molecular mass of polymer (MMP) on the binodal and tie-line compositions were studied. Results showed that the biphasic area was extended as the MMP was increased. The salting-out ability were quantified using the Setschenow model, and the binodal curves were modeled by a nonlinear 3-parameter equation. Furthermore, electrolyte Wilson along with the osmotic virial models have adequately been implemented to fit the tie-line compositions. Also, the studied ATPSs were implemented to study the partitioning of salbutamol drug on the salt-affluent and polymer-affluent phases. It is observed that, ATPSs of PEG is premium to extract the salbutamol to the polymer-affluent phase, where, the ATPSs of PEG is more favorable to extract the drug to the salt-affluent phase.

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