Thorectidiol A Isolated from the Marine Sponge Disrupts Interactions of the SARS-CoV-2 Spike Receptor Binding Domain with the Host ACE2 Receptor

Overview

Journal J Nat Prod

Date 2023 Jan 19

PMID 36657039

Authors

David E Williams

Joel Cassel

Jin-Lin Zhu

Jian-Xiong Yang

Nicole J de Voogd

Teatulohi Matainaho

Joseph M Salvino

Yan Alexander Wang

Luis J Montaner

Ian Tietjen

Raymond J Andersen

Affiliations

Soon will be listed here.

Abstract

Thorectidiols isolated from the marine sponge (family Thorectidae, order Dictyoceratida) collected in Papua New Guinea are a family of symmetrical and unsymmetrical dimeric biphenyl meroterpenoid stereoisomers presumed to be products of oxidative phenol coupling of a co-occurring racemic monomer, thorectidol (). One member of the family, thorectidiol A (), has been isolated in its natural form, and its structure has been elucidated by analysis of NMR, MS, and ECD data. Acetylation of the sponge extract facilitated isolation of additional thorectidiol diacetate stereoisomers and the isolation of the racemic monomer thorectidol acetate (). Racemic thorectidiol A () showed selective inhibition of the SARS-CoV-2 spike receptor binding domain (RBD) interaction with the host ACE2 receptor with an IC = 1.0 ± 0.7 μM.

Citing Articles

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