Integrative Analysis of Gene and Protein Expression in Atherosclerosis-related Pathways Modulated by Periodontal Pathogens. Systematic Review

Overview

Journal Jpn Dent Sci Rev

Publisher Elsevier

Specialty Dentistry

Date 2023 Jan 19

PMID 36654677

Authors

Talia Yolanda Marroquin

Sandra Guauque-Olarte

Affiliations

Soon will be listed here.

Abstract

Methods: Cochrane, PRISMA and AMSTAR2 guidelines for systematic reviews were followed. Data search was conducted in Pub-med, LILACS and Science Direct databases. Gene and protein expression data were collected from the included papers to perform an overrepresentation analysis using the Reactome Pathway Analysis tool and the KEGG database.

Results: Thirty-two papers were included in the review, they analyzed the effect of , , , , , and or/and their virulent factors on gene and protein expression in human cells and animal models of atherosclerosis. Some of the modulated pathways include the immune system, programmed cell death, cellular responses to external stimuli, transport of small molecules, and signal transduction (p < 0.05). Those pathways are known to be involved in different stages of atherosclerosis progression.

Conclusion: Based on the performed analysis, it is possible to state that periodontal pathogens have the potential to be a contributing factor for atherosclerosis even in absence of a high-fat diet or high shear stress.

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