Could Paraprobiotics Be a Safer Alternative to Probiotics for Managing Cancer Chemotherapy-induced Gastrointestinal Toxicities?

Overview

Journal Braz J Med Biol Res

Specialties Biology
General Medicine

Date 2023 Jan 18

PMID 36651453

Authors

L M S Nobre

C Fernandes

K G D Florencio

N M N Alencar

D V T Wong

R C P Lima-Junior

Affiliations

Soon will be listed here.

Abstract

Clinical oncology has shown outstanding progress improving patient survival due to the incorporation of new drugs. However, treatment success may be reduced by the emergency of dose-limiting side effects, such as intestinal mucositis and diarrhea. Mucositis and diarrhea management is symptomatic, and there is no preventive therapy. Bacterial and fungal-based compounds have been suggested as an alternative for preventing the development of diarrhea in cancer patients. Using probiotics is safe and effective in immunocompetent individuals, but concerns remain during immunosuppressive conditions. Paraprobiotics, formulations composed of non-viable microorganisms, have been proposed to overcome such limitation. The present literature review discusses current evidence regarding the possible use of paraprobiotics as an alternative to probiotics to prevent gastrointestinal toxicity of cancer chemotherapy.

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