DNA Strand Breaks and Denaturation As Probes of Chemical Reactivity Versus Thermal Effects of Atmospheric Pressure Plasma Jets

Overview

Journal ACS Omega

Publisher American Chemical Society

Specialty Chemistry

Date 2023 Jan 16

PMID 36643434

Authors

Amal Sebastian

Daniel Lipa

Sylwia Ptasinska

Affiliations

Soon will be listed here.

Abstract

An atmospheric pressure plasma jet (APPJ) is being advanced as an alternative radiation type that offers excellent efficacy in an array of medical applications against specific biological targets such as DNA. This work explores the possibility of implementing DNA and its damage as a probe for specific plasma diagnostics such as reactive plasma species formation and transient local heating. We analyzed both APPJ characteristics based on the detection of plasma-induced strand breaks and DNA denaturation. Further, we implemented a machine learning model based on artificial neural networks to predict the type and extent of DNA damage for a given combination of APPJ parameter values. This methodology is an important step toward deciphering and explaining the potential adverse effects of APPJ on biological samples of any prospective interest in medicine.

Citing Articles

Exploring pH Dynamics in Amino Acid Solutions Under Low-Temperature Plasma Exposure.

Villavicencio C, Silva B, Matara A, Ptasinska S Molecules. 2025; 29(24.

PMID: 39769978 PMC: 11679283. DOI: 10.3390/molecules29245889.

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