Role of Mitophagy in the Hallmarks of Aging

Overview

Journal J Biomed Res

Specialty General Medicine

Date 2023 Jan 16

PMID 36642914

Authors

Jie Wen

Tingyu Pan

Hongyan Li

Haixia Fan

Jinhua Liu

Zhiyou Cai

Bin Zhao

Affiliations

Soon will be listed here.

Abstract

Aging, subjected to scientific scrutiny, is extensively defined as a time-dependent decline in functions that involves the majority of organisms. The time-dependent accretion of cellular lesions is generally a universal trigger of aging, while mitochondrial dysfunction is a sign of aging. Dysfunctional mitochondria are identified and removed by mitophagy, a selective form of macroautophagy. Increased mitochondrial damage resulting from reduced biogenesis and clearance may promote the aging process. The primary purpose of this paper is to illustrate in detail the effects of mitophagy on aging and emphasize the associations between mitophagy and other signs of aging, including dietary restriction, telomere shortening, epigenetic alterations, and protein imbalance. The evidence regarding the effects of these elements on aging is still limited. And although the understanding of relationship between mitophagy and aging has been long-awaited, to analyze details of such a relationship remains the main challenge in aging studies.

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